Activity of cyclic nucleotide-gated (CNG) cation channels underlies signal transduction in vertebrate visual receptors. These highly specialized receptor channels open when they bind cyclic GMP (cGMP). Here, we find that certain mutations restricted to the region around the ion selectivity filter render the channels essentially fully voltage gated, in such a manner that the channels remain most...

weirs have widely been used for the flow measurement, flow diversion and its control in the open channels. attempts have been made to study flow over different shapes of normal weirs, side weirs and oblique weirs. this paper is connected with the development of the discharge coefficient measurement. in the present study four different weirs in different height are considered for validation purp...

normal 0 false false false en-us x-none ar-sa microsoftinternetexplorer4 introduction: providing free access to the latest research and more publishing channels, open access (oa) is hoped to decrease the south countries' information poverty and professional isolation. due to its particular importance, it is necessary to investigate how they exploit open access resources. methods: applying a cit...

This paper applies an evolutionary algorithm, the particle swarm optimization (PSO), to design the optimum open channel section. Depth, channel side slope and bottom width are considered as the variables for rectangular, triangular and trapezoidal channels, respectively. The objective function is minimizing the construction cost of the channel section. MATLAB software is used for programming an...

In this paper, two compact quad-channel and six-channel diplexer are designed and fabricated using defected microstrip structure (DMS). This structure is designed for the desired frequency based on the literature reviews. The proposed configuration is composed of a conventional T-junction divider with two pairs of open bended stubs and dual/tri-band filters. In designing dual band filters, a lo...

Gap junction channels provide the basis for intercellular communication and play an important physiological role in the cardiovascular system for maintenance of the normal cardiac rhythm, regulation of vascular tone, endothelial function and myoendothelial interaction as well as for metabolic interchange between the cells. Thus, pharmacological influence on these channels might help to elucidat...

Pacemaker (HCN) channels are hyperpolarization-activated and their activity is enhanced by cyclic AMP (CAMP), but whether CAMP-gating is coupled to voltage-gating remains unresolved. With long hyperpolarizations, HCN channels form a secondary open state after the initial opening; this briefly sustains the activation of open channels after a return to a resting voltage. CAMP effects on the forma...

  Objective(s): Recently, phthalimide derivatives were designed based on ameltolide and thalidomide as they possess a similar degree of anticonvulsant potency due to their phenytoin-like profile. The ability of phthalimide pharmacophore to interact with neuronal voltage-dependent sodium channels was studied in the batrachotoxin affinity assay. Therefore, in the present study, a series of 19 com...