We have examined meiotic recombination at the CYS3 locus. Genetic analysis indicates that CYS3 is a hotspot of meiotic gene conversion, with a putative 5'-3' polarity gradient of conversion frequencies. This gradient is relieved in the presence of msh2 and pms1 mutations, indicating an involvement of mismatch repair functions in meiotic recombination. To investigate the role of mismatch repair ...

background:diabetic foot affects more than 25% of diabetic patients and finally up to 20% of cases result in amputation. the most important factor resulting in severe complications or even death is lack of self-care. health locus of control has been introduced as one of health factors and predicting factors of self-care. this research was performed for analyzing the correlation between self-car...

This study examined the experiential attitude function—an attitude based on past experience(s)—and tested whether a message targeted at this function would elicit attitude change. Each of 139 undergraduates was assigned randomly to one of four conditions in which a fictitious Executive Committee for Academic Integrity (ECAI) report, written for a university president, supplied strong or weak ar...

In this paper, we aim to understand whether current language and vision (LaVi) models truly grasp the interaction between the two modalities. To this end, we propose an extension of the MSCOCO dataset, FOIL-COCO, which associates images with both correct and ‘foil’ captions, that is, descriptions of the image that are highly similar to the original ones, but contain one single mistake (‘foil wo...

BACKGROUND Successful engraftment of hematopoietic stem cells from unrelated donors is influenced by disparities between the donor and recipient for HLA-A, B, and C alleles. Disparities between HLA sequence polymorphisms that are serologically detectable are termed antigen mismatches, whereas those that can be identified only by DNA-based typing methods are termed allele mismatches. Whether bot...

The Huntington's disease gene (HTT) CAG repeat mutation undergoes somatic expansion that correlates with pathogenesis. Modifiers of somatic expansion may therefore provide routes for therapies targeting the underlying mutation, an approach that is likely applicable to other trinucleotide repeat diseases. Huntington's disease Hdh(Q111) mice exhibit higher levels of somatic HTT CAG expansion on a...

Background:Diabetic foot affects more than 25% of diabetic patients and finally up to 20% of cases result in amputation. The most important factor resulting in severe complications or even death is lack of self-care. Health locus of control has been introduced as one of health factors and predicting factors of self-care. This research was performed for analyzing the correlation between self-car...

Determining true genetic dissimilarity between individuals is an important and decisive point for clustering and analysing diversity within and among populations, because different dissimilarity indices may yield conflicting outcomes. We show that there are no acceptable universal approaches to assessing the dissimilarity between individuals with molecular markers. Different measures are releva...

Spontaneous hydrolytic deamination of 5-methylcytosine leads to T:G mismatches in double-stranded DNA and comprises a major threat for the integrity of both the DNA primary sequence as well as the epigenetic information stored in the DNA methylation pattern. Failure ofthe cellular DNA repair machinery to recognize and repair such mismatched nude otides can lead to a mutator phenotype and subseq...

DNA methylation is an important epigenetic regulation of gene transcription. Locus-specific DNA methylation can be used as biomarkers in various diseases including cancer. Many methods have been developed for genome-wide methylation analysis, but molecular diagnotics needs simple tools to determine methylation states at individual CpG sites in a gene fragment. In this report, we utilized the na...