We describe the first analytical method involving SPE and CZE coupled to ESI-IT MS (CZE-ESI-MS) used to identify and characterize phenolic compounds in olive oil samples. The SPE, CZE and ESI-MS parameters were optimized in order to maximize the number of phenolic compounds detected and the sensitivity of their determination. To this end we have devised a detailed method to find the best condit...

In this study, it was surveyed to know whether an oral single dose of oleuropein could mimic the cardiac preconditioning in rats’ hearts or whether its prolonged oral administration could protect the heart against the aconitine-induced arrhythmia in rats. Eighty male Wistar rats were divided into two series (n = 8 in each group). In the first series, all groups (except the control (Con) group) ...

The possibility to improve the nutritional value of olive oil by enriching it in phenolic compounds from olive leaves (e.g., oleuropein) by ultrasonic maceration was studied. The experimental design used led to the following optimal extraction conditions: ultrasonic power of 60 W, temperature of 16°C and sonication duration of 45 min. The high total phenolic content (414.3 ± 3.2mg of oleuropein...

Oleuropein, one of the main polyphenolic constituents olive, is cardioprotective against ischemia reperfusion injury (IRI). We aimed to assess cardioprotection afforded by acute administration oleuropein and evaluate underlying mechanism. Importantly, since antioxidant therapies have yielded inconclusive results in attenuating IRI-induced damage on top conditioning strategies, we investigated w...

background: neutrophil infiltration plays an important role in inflammatory reactions following spinal cord injury (sci) and these cells cause substantial secondary tissue damage. the purpose of this study was to determine the effect of oleuropein (oe) on myeloperoxidase (mpo) activity as an index of neutrophil infiltration. methods: rats were randomly divided into four groups of 7 rats each as...

Olives and olive oil contain large amounts of oleuropein. This phenolic compound is responsible for theirbitter taste and pungent aroma and has been recognized as a powerful hypotensive, hypoglycemic andantioxidant agent. Thus, the aim of the present study was to evaluate the antioxidant properties of oleuropein on ethanol-induced oxidative damage and to examine its beneficial effects on liver ...

A new high-pressure liquid chromatography multidetection quantitative method for the isolation of the products of oleuropein hydrolysis is described. A single analysis yields sufficient amounts of the compounds to test their inhibitory effect on bacterial growth.

Corresponding Author: Ali Reza khalatbary Molecular and Cell Biology Research Center, Department of Anatomy, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran. Phone: +98 1133200894 E-mail: [email protected] Abstract Background: Deltamethrin (DM) is a synthetic pyrethroid insecticide that can elicit neurotoxicity, and lead to apoptosis. There is accumulating evidence t...

objective: olive oil and olive leaf extract are used for treatment of skin diseases and wounds in iran. the main component of olive leaf extract is oleuropein. this research is focused on the effects of oleuropein on skin wound healing in aged male balb/c mice. materials and methods: in this experimental study, oleuropein was provided by razi herbal medicine institute, lorestan, iran. twenty fo...