We tested whether Ca(2+)-mobilizing neuropeptides can function as growth factors for small cell lung carcinoma cells. The neuropeptides bradykinin, neurotensin, cholecystokinin, and vasopressin at nanomolar concentrations stimulated a rapid and transient increase in the intracellular concentration of Ca2+. Crucially, these peptides in the same concentration range also caused a marked increase i...

Many neuropeptides and peptide hormones are very similar to antimicrobial peptides in their amino acid composition, amphipathic design, cationic charge and size. Their antimicrobial activities suggest they may also be directly involved in innate defense. Here we discuss recent advances in understanding how the mammalian nervous system, equipped with neuropeptides and peptide hormones with poten...

PURPOSE To investigate the subcutaneous injection of carbon dioxide (CO2) on neuropeptides Calcitonin Gene-Related Peptide (CGRP) and Substance P (SP) secretion in rat skin. METHODS Fifty-six Wistar-EPM rats were distributed in two groups: one for CGRP analysis, the other for SP analysis. Each group was subdivided into four subgroups: control (Cont), control with needle (ContNd), CO2 injectio...

Biomimetic Periosteum In article 2203027 by Yanlin Su, Kaifang Chen, Daping Quan, Xiaodong Guo, and co-workers, [email protected] electroactive biomimetic periosteum is created, which can regulate the concentration of axon initial segments in sensory nerves, promote bone regeneration releasing neuropeptides. This will enrich theory neurogenic provide a promising treatment for defects.

Thanks to advances in DNA sequencing and bioinformatics methods, for many species we know their genomic sequence as well as sequences of proteins produced by their cells. However, the exact function of those proteins is often unknown. The goal of our work is to automatically recognize neuropeptides, special proteins involved in communication between neurons. Neuropeptides are created in a cell ...