Breast cancer is the fifth most common cause of death among women worldwide. Resistance to cisplatin is a main challenge in its treatment. Our present aim was to prepare nanoniosomated cisplatin and examine its efficacy in vitro using the BT-20 cell line. Niosome nanoparticles containing cisplatin were prepared by reverse-phase evaporation and characterized by dynamic light scattering (DLS), sc...

Drug resistance to conventional chemotherapeutics is a great impediment cancer therapy. A major part of this problem arises from rapid metabolism the drugs by cytochrome P450 class enzymes before they reach their targets or at target itself. Inhibition such enzymatic deactivation could offer partial rescue and make chemotherapy more effective. Site specific delivery exogenous carbon monoxide ha...

Nanotechnology has been extensively explored for drug delivery. Here, we introduce the concept of a nanodrug based on synergy of photothermally-activated physical and biological effects in nanoparticle-drug conjugates. To prove this concept, we utilized tumor necrosis factor-alpha coated gold nanospheres (Au-TNF) heated by laser pulses. To enhance photothermal efficiency in near-infrared window...

Abstract Nanotechnology consist of using materials at the nanoscale, in which they acquire specific characteristics. Nanodrug research and development is one most promising fields today; however, these particles require particular evaluation. Moreover, studies lack consensus on tests to follow, thus hindering elaboration legislation that ensure their safety efficacy, as well a more effective re...

Small molecule-based nanodrugs with nanoparticles (NPs) that are mainly composed of small molecules, have been considered as a promising candidate for a next-generation nanodrug, owing to their unique properties. Vorinostat (SAHA) is a canonical US Food and Drug Administration-approved histone deacetylase (HDAC) inhibitor for the treatment of cutaneous T-cell lymphoma. However, the lack of effi...

Self-assembled nanoparticles of the natural polymer, silk fibroin (SF), are a very promising candidate in drug delivery due to their biocompatible and biodegradable properties. In this study, SF nanoparticles loaded with 5-fluorouracil (5-FU) and curcumin with size 217±0.4 nm and with a loading efficacy of 45% and 15% for 5-FU and curcumin, respectively, were prepared. The in vitro release effe...

Conventional evaluation methods of chemotherapeutic efficacy such as tissue biopsy and anatomical measurement are either invasive with potential complications or dilatory to capture the rapid pathological changes. Here, a sensitive and resolution-scalable photoacoustic microscopy (PAM) with theranostic nanoformulation was developed to noninvasively monitor the therapy response in a timely manne...

Abstract Arsenic trioxide (ATO) is a promising chemotherapeutic agent, but its clinical application limited due to poor pharmacokinetics and dose-limited toxicity. Moreover, the combination of ATO sec-o-glucosylhamaudol (SOG) can improve therapeutic effect hepatoma. In this study, PEGylated magnetic nanographene oxide (PEG@MGO) was used as carriers enhance targeting ability drug delivery system...

Hepatocellular carcinoma or hepatoma is a primary malignant neoplasm that responsible for 75–90% of all liver cancer in humans. Nanotechnology introduced the dual drug nanodelivery method as one initiatives nanomedicine therapy. Graphene oxide (GO) loaded with protocatechuic acid (PCA) and chlorogenic (CA) have shown some anticancer activities both passive active targeting. The physicochemical ...