the highly conserved morphology and chromosomal structures of house mouse, mus musculus, provides a good model for chromosomal studies. sex-autosome translocations is one of the rarest chromosomal rearrangements among mammals and therefore sex-autosome translocations has been offered as accurate taxonomic markers to identify species with similar morphological traits. in this study, we described...

most of the systematic studies used in the development of human embryo culture media have been done first on mouse embryos. the general use of nmri outbred mice is a model for toxicology, teratology and pharmacology. nmri mouse embryo exhibit the two-cell block in vitro. the objective of this study was to evaluate and compare the effects of four kinds of culture media on the development of zygo...

Background: Vitrification has been usually used as an assisted reproductive technology in animals and humans. This method needs high concentrations of cryoprotectants that can be toxic with high cooling degrees. Then, vitrification could be change histone modifications such as methylation and acetylation can performance as regulatory controls of gene transcription. So, the purpose of the presen...

background: black seed (bs) is used in traditional medicine as a therapy for a variety of diseases including allergic asthma. materials and methods: in the present study, anti-inflammatory and immunomodulatory effects of bs on cytokine gene expression, lung airway eosinophilia and goblet cell hyperplasia were examined in a mouse mice model of allergic asthma. groups of 6-week-old female balb/c ...

background: it has been hypothesized that blastocyst integrin expression changes can affect the spontaneous miscarriage in polycystic ovarian syndromes (pcos). objective: in this study, the profile of integrin genes and proteins was investigated on blastocyst of the pcos experimental mouse model. materials and methods: 30 nmri female mice were equally divided into 3 groups: control, experimenta...

contact hypersensitivity (chs) mouse model induced by 2, 4-dinitrofluorobenzene (dnfb) is thought to be a t helper 1 (th1)-dominant response and used for investigating anti-inflammatory and immunosuppressive agents. however, it is hardly used for screening large-scale drugs because of the large number of animals and complex mechanisms involved in-vivo. in this study, we focused on whether t lym...

givotia rottleriformis has been used in the indigenous systems of medicine for the treatment of inflammatory diseases like rheumatism and psoriasis. in order to evaluate this information, antipsoriatic activity of three flavonoids isolated from the ethanol extract of the bark of givotia rottleriformis were investigated using in-vitro and in-vivo model, namely rutin (i), luteolin-7-o-β-d-glucuro...

In this issue of Neuron, Espuny-Camacho et al. (2017) generate a humanized Alzheimer's disease (AD) model that reveals species-specific vulnerability of human neurons to AD pathology. This model provides key insights for disease mechanism and therapeutic discovery for AD.

introduction: the most common mode of rabies virus transmission is through a bite wound or contact of broken skin with saliva of a rabid animal. various other routes of virus transmission include exposure of mucous membranes (i.e. eyes, nose, and mouth) to infected saliva of a rabid animal, aerosol transmission, and corneal transplantation. laboratory workers during work with rabies virus and v...

cow’s milk whey consists of many protein components and some of them are antigens to human and known to modulate immune responses. enzymatic hydrolysis is a useful method to modify proteins with allergenicity. the objective of this study was to identify whether the in vitro enzymatic hydrolysis could reduce the allergenicity of whey protein concentrates (wpc). in  this study, wpc were hydrolyze...