Background—The p21 gene mediates growth arrest by inhibiting G1 cyclin dependent kinases and has been considered as a downstream eVector of the tumour suppressor gene p53. Aim—To analyse the role of p21 in gestational trophoblastic disease. Methods—The immunohistochemical expression of p21 gene was measured in 33 placentas, 28 partial hydatidiform moles, 54 complete hydatidiform moles, and 13 c...

A dynamic equilibrium has been found in CDCl3 between a neutral molecular square, [cis-Mo2(DAniF)2]4(O2CC6F4CO2)4 (1) and triangle, [cis-Mo2(DAniF)2]3(O2CC6F4CO2)3 (2) (DAniF = the anion of N,N'-di-p-anisylformamidine). The two components have been crystallographically characterized and solution studies by 1H and 19F NMR spectra of the concentration- and the temperature-dependence of the equili...

Animals adapted to dark ecotopes may experience selective pressure for retinal reduction. No previous studies have explicitly addressed the molecular basis of retinal development in any fossorial mammal. We studied retinal development and function in the Iberian mole Talpa occidentalis, which was presumed to be blind because of its permanently closed eyes. Prenatal retina development was relati...

In 1935 Negelein and Haas described a method for the determination of glucose 6-phosphate dehydrogenase activity based on measurement of the rate of reduced triphosphopyridine nucleotide formation from triphosphopyridine nucleotide (1). Since that time innumerable enzymes and substrates have been measured by the appearance or disappearance of reduced diphosphopyridine nucleotide or reduced trip...