نتایج جستجو برای: mir 103a 3p

تعداد نتایج: 49246  

Journal: :Applied Biological Chemistry 2022

Abstract Recent researches indicate the key role of circRNA in gastric cancer (GC) progression. However, circ_0026359 GC progression remains unclear. This study aims to analyze development and underlying mechanism. The results showed that compared with controls, tissues cells displayed high HOXA9 expression, low miR-140-3p expression. Depletion repressed cell proliferation, migration, invasion ...

Journal: :American journal of physiology. Cell physiology 2016
Liu Qingjuan Feng Xiaojuan Zhang Wei Wu Chao Kang Pengpeng Li Hongbo Zhang Sanbing Hao Jun Yang Min Liu Shuxia

The objective of this study was to investigate the role of miR-148a-3p in lupus nephritis (LN) based on data from previous studies and a microRNA assay. We evaluated the miR-148a-3p expression level in LN renal tissues and blood serum to determine its clinicopathological significance and effect on glomerular cell proliferation. Then, we collected renal glomeruli from LN mice and determined the ...

2017
Jili Su Eryong Lu Lijuan Lu Chao Zhang

MicroRNAs (miRNAs) are known to play a regulatory role in various cancers including laryngocarcinoma. MiR-29a-3p is a potential tumor-suppressive miRNA, but its function in laryngocarcinoma is unknown. The purpose of this study was to investigate the roles of miR-29a-3p in laryngocarcinoma. Prominin1 (PROM1) was predicted as a target gene of miR-29a-3p and this was verified using a luciferase r...

2016
Chun-Mei Tang Fang-zhou Liu Jie-Ning Zhu Yong-Heng Fu Qiu-Xiong Lin Chun-Yu Deng Zhi-Qin Hu Hui Yang Xi-Long Zheng Jian-Ding Cheng Shu-Lin Wu Zhi-Xin Shan

The role of microRNA-214-3p (miR-214-3p) in cardiac hypertrophy was not well illustrated. The present study aimed to investigate the expression and potential target of miR-214-3p in angiotensin II (Ang-II)-induced mouse cardiac hypertrophy. In mice with either Ang-II infusion or transverse aortic constriction (TAC) model, miR-214-3p expression was markedly decreased in the hypertrophic myocardi...

Journal: :Nephrology Dialysis Transplantation 2023

Abstract Background and Aims Hyperuricemia (HN) is a threat for the occurrence of renal interstitial fibrosis (RIF). Dysfunctional histone deacetylase 3 (HDAC3) elicit damage. This study aimed to explore role HDAC3 in HN-induced RIF from microRNA-19b-3p/splicing factor 3b subunit (miR-19b-3p/SF3B3) axis. Method 1. The HN model was established on rats induce by oral administration adenine potass...

2016
Deokbum Park Hyuna Kim Youngmi Kim Dooil Jeoung

We have previously reported the role of miR-217 in anti-cancer drug-resistance. miRNA array and miRNA hybridization analysis predicted miR-30a-3p as a target of miR-217. miR-30a-3p and miR-217 formed a negative feedback loop and regulated the expression of each other. Ago1 immunoprecipitation and co-localization analysis revealed a possible interaction between miR-30a-3p and miR-217. miR-30a-3p...

Journal: :Archives of Medical Science 2021

Introduction Type 2 diabetes mellitus (T2DM) is a major kind of mellitus. This study aimed to analyze the regulatory effect long noncoding RNA NBR2 on pancreatic  cell function and related mechanisms, clinical significance abnormal expression in patients with T2DM. Material methods The levels microRNA-19a-3p (miR-19a-3p) were measured using quantitative Real-Time PCR. glucose-stimulated insuli...

2017
Maosong Lin Bensong Duan Jiangfeng Hu Hong Yu Haihui Sheng Hengjun Gao Junxing Huang

Epithelial-mesenchymal transition (EMT) is an early and key process in the metastatic cascade during the progression of colorectal cancer (CRC). The aim of the present study was to identify deregulated EMT-related microRNAs (miRNAs/miRs) of CRC and assess the effect of differentially expressed miRNAs on the prognosis of patients with CRC. Genome-wide expression profiling of miRNAs was assessed ...

2017
Jing-Song Chen Li-Li Liang Hong-Xu Xu Fan Chen Shun-Li Shen Wei Chen Lian-Zhou Chen Qiao Su Long-Juan Zhang Jiong Bi Wen-Tao Zeng Wen Li Ning Ma Xiao-Hui Huang

Down-regulation of the miRNA miR-338-3p correlates with the invasive ability of hepatocellular carcinoma (HCC) cells. However, it is currently unclear whether down-regulation of miR-338-3p induces epithelial-mesenchymal transition (EMT), which may be the underlying mechanism governing HCC invasion. Here, we demonstrate that restoration of miR-338-3p expression via transfection of a miR-338-3p m...

2018
Yibing Li Jianing Huo Xin Pan Cuicui Wang Xiaoxin Ma

Background Studies have shown that the microRNA miR-302 can affect the proliferation, migration and cell cycle progression of endometrial carcinoma (EC). miR-302 clusters have been shown to play an important role in the proliferation and differentiation of cancer cells and in their tumorigenicity. Subjects and methods In this study, we detected the expression of genes through quantitative rev...

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