Background and Objectives: Acrylamide is a monomer which is formed in foodstuffs containing carbohydrates altered to asparagine during thermal processing. Vitamin E is a component in human diet considered as the most effective lipid-soluble antioxidant found in the biological system. It prevents initiation of oxidative tissue...

In the present study, effects of Origanum onites L. extract and essential oil O. on antioxidant status liver brain mice were investigated. Due to certain disadvantages oils, such as poor solubility, high volatility sensitivity UV light heat, formulation liposomes with Oregano essentials (OE) was optimized used in this study. The results demonstrated that best composition lipid carriers OE condu...

Liver is a major organ of the body which can be exposed to various chemicals, drugs, and many other xenobiotics such as bromobenzene. Bromobenzene must be converted to its active metabolites to produce liver and kidney toxicity. Livergol is an herbal product which contains silymarin. The objective of this study was to find out the protective effect of livergol against liver toxicity induced by ...

objective(s) pde3 has a functional role in insulin secretion and action. we investigated the metabolic effects of new synthetic pde3 inhibitors (mc1, mc2, mc5 and mc6), on mice and hyperglycemic rat. materials and methods the test compound or solvent was injected subcutaneously to mice, for 7 days. on day 8, blood and liver samples were obtained. in hyperglycemic rat, 0.5 g/kg glucose with or w...

To evaluate the impact of gender and ablation β-carotene oxygenase 1 (BCO1), 2(BCO2) or both on tissue accumulation lycopene dosed transgenic mice. Previous work from our laboratories suggests that BCO2 appears to be primary carotenoid cleavage enzyme for in vivo. Three-week old C57BL/6 male female mice (wild type [WT], Bco1-/-, Bco2-/-, Bco1-/- X Bco2-/- double knock out [DKO]) were divided in...

The early-phase migration dynamics of Echinococcus multilocularis in the intermediate hosts remain largely unknown. We compared parasite burden intestine, liver and faeces DBA/2 C57BL/6 mouse strains using parasite-specific quantitative PCR. Our results indicated that parasites invaded mainly from middle segments small intestine completed to within 24 h p.i. mice had lower DNA burdens but highe...

aim : to create an orthotopic hepatoma model with local metastasis monitored with ultrasound could be created as a platform for testing new treatments.   background : hepatoma accounts for 25% of liver tumors in children with poor overall survival. intraabdominal metastasis are present in 35% of patients at time of diagnosis.  we hypothesized that an orthotopic tumor model with local metastasis...

• Tetrahydrocurcumin (THC) improves glucose and lipid metabolism disorders in nonalcoholic fatty liver disease (NAFLD) mice. THC regulates the expression of oxidoreductase genes lipid-metabolizing enzyme NAFLD increases antioxidant capacity inhibits deposition HepG2 cells by activating NRF2 signaling pathway. Nonalcoholic is most common metabolic world. In this study we investigated effect tetr...