OBJECTIVE To evaluate bronchial challenges using three different stimuli as screening tools for bronchial hyper-responsiveness in sulfur mustard gas-induced asthma. DESIGN Randomized, cross-over clinical study. SETTING University hospital. PATIENTS Eighteen veterans with mustard gas-induced asthma and 18 normal veterans as the control group. INTERVENTION Pulmonary function tests and inh...

In the European Community Respiratory Health Study (ECRHS), airway responsiveness to methacholine was determined using the Mefar dosimeter protocol. Elsewhere, the 2-min tidal breathing method has become the preferred standardized method. The relationship between measurements of responsiveness by these two methods is not well established. This study measured airway responsiveness to methacholin...

OBJECTIVE To evaluate the effectiveness and onset of action of formoterol delivered by dry-powder inhaler in reversing methacholine-induced bronchoconstriction. METHODS Patients presenting a drop in forced expiratory volume in one second > 20% after methacholine inhalation were included. A total of 84 patients were evaluated. All of the participating patients presented respiratory symptoms of...

Introduction According to the reports of the United States National Bureau of Statistics regarding the prevalence of obesity among adults and children and also asthma outbreak, the relationship between asthma and obesity in developed countries is taken into consideration. Aim Relationship between body mass index and increased airway reactivity based on methacholine challenge test results. M...

This paper presents a method for bioassay of vasotropic substances. Data on the accuracy of the method are presented in terms of the response to repeated injections of methacholine. Some of the factors affecting the response to methacholine are analyzed. The peripheral vasodilator effect of a nondialyzable substance present in human urine is demonstrated and the effectiveness of this substance ...

This paper presents a method for bioassay of vasotropic substances. Data on the accuracy of the method are presented in terms of the response to repeated injections of methacholine. Some of the factors affecting the response to methacholine are analyzed. The peripheral vasodilator effect of a nondialyzable substance present in human urine is demonstrated and the effectiveness of this substance ...

Muscarinic receptors and platelet-derived growth factor (PDGF) receptors synergistically induce proliferation of airway smooth muscle (ASM), but the pathways that regulate these effects are not yet completely identified. We hypothesized that glycogen synthase kinase-3 (GSK-3), a kinase that represses several promitogenic signaling pathways in its unphosphorylated form, is cooperatively inhibite...

: Anticholinergics, or specific antimuscarinic agents, by inhibition of muscarinic receptors cause bronchodilatation, which might correlate with activation of these receptors by the muscarinic agonist methacholine. The aim of this study was to determine whether a positive bronchodilator response to the anticholinergic ipratropium bromide could predict airway hyperresponsiveness in patients with...

Background: The methacholine bronchial provocation test is a useful tool for evaluating asthma in patients with normal or near normal baseline lung function. However, the sensitivity of this test is 82∼92% at most. The purpose of this study is to evaluate the clinical usefulness of FEF25-75% in identification of airway hyperresponsiveness in patients with suspected asthmatic symptoms. Methods: ...

Methacholine (MCh) challenge testing is often incorporated into clinical studies prior to performing bronchoscopy as a measure of bronchial hyperresponsiveness (BHR). However, the effect of methacholine on many aspects of bronchoalveolar lavage (BAL) fluid cell count and function have not been fully evaluated. Ten patients with asthma, maintained on inhaled beta 2-agonists, were studied. Each s...