Denote by B∗ n the set of all k∗-cycle resonant hexagonal chains with n hexagons. For any Bn ∈ B ∗ n , let m(Bn) and i(Bn) be the numbers of matchings (=the Hosoya index) and the number of independent sets (=the Merrifield-Simmons index) of Bn, respectively. In this paper, we give a characterization of the k∗-cycle resonant hexagonal chains, and show that for any Bn ∈ B ∗ n , m(Hn) ≤ m(Bn) and ...

The research tradition stemming from the cross-language study of color terms of Berlin and Kay (1969) and most recently embodied in Kay, Berlin, Maffi and Merrifield (1997) and Kay and Maffi (in press) has been criticized on the grounds (1) that many languages contain words which express both color and non-color properties, (2) that in many languages words which express color properties do not ...

Synthesis on solid phase is one of modern methodologies especially useful in parallel and combinatorial syntheses. Tertiary amine functionalities are found in many important classes of catalysts, reagents and biologically active compounds. The tertiary N-methyl group is also present in structures of tropane alkaloids and majority of synthetic tropane derivatives with potential biological activi...

We have developed a convenient method for the direct synthesis of peptide thioesters, versatile intermediates for peptide ligation and cyclic peptide synthesis. The technology uses a modified Boc SPPS strategy that avoids the use of anhydrous HF. Boc in situ neutralization protocols are used in combination with Merrifield hydroxymethyl resin and TFA/TMSBr cleavage. Avoiding HF extends the scope...

The impact of combinatorial chemistry of small molecules on the drug discovery process is now widely recognized by the scientific community [1]. Solid-phase organic synthesis (SPOS) is a valuable tool for the generation of structurally diverse compounds for combinatorial libraries. In our work dealing with the solid-phase synthesis of biologically interested compounds, we have developed methodo...

A. D. Morse (1), S. J. Barber (1), K. R. Dewar (1), J. M. Pillinger (1), S. Sheridan (1), I. P. Wright (1), E. K. Gibson (2), J. A. Merrifield (3), C. J. Howe (4), L. J. Waugh (5) and C. T. Pillinger (1) (1) Planetary & Space Sciences, The Open University, Walton Hall, Milton Keynes. MK7 6AA UK, (2) Astromaterials Research Office, NASA Johnson Space Center, Houston, TX 77058, USA, (3) Fluid Gra...

Cyclopropanation reaction is an important tool for obtaining interesting compounds and can be catalyzed by metalloporphyrins with high syn/anti ratio. The catalyst cannot be recycled and is usually lost during chromatographic separation from the two isomeric products. In this paper a meso-tetraphenylporphyrin rhodium(III) chloride was bound to a Merrifield resin and used to catalyze the cyclopr...