Background Recent studies revealed that tumor-associated macrophages (TAMs) play a decisive role in the regulation of tumor progression by manipulating tumor oncogenesis, angiogenesis and immune functions within tumor microenvironments. Signal transducer and activator of transcription 3 (STAT3), which is a point of convergence for numerous oncogenic signalling pathways, is constitutively activ...

The emergence of new COVID-19 infection aggravated the existing issues and gave rise to challenges associated with impact viruses on atherosclerotic process development cardiovascular complications. Atherosclerosis is a multifactorial disease its progression largely determined by dyslipidemia chronic low-grade systemic vascular inflammation. There are number known be involved in maintaining inf...

Compared to cellular immunotherapy, engineering macrophage-derived EVs which carry nanoparticles, drugs, proteins, nucleic acids etc. can target tumor cells improve biosafety and treatment efficacy.

Wnt5a is implicated in development and tissue homeostasis by activating β-catenin-independent pathway. Excessive production of Wnt5a is related to some human diseases. Macrophage recruitment is a character of inflammation and cancer, therefore macrophage-derived Wnt5a is supposed to be a player in these conditions. Actually, macrophage-derived Wnt5a maintains macrophage immune function, stimula...

The present study was carried out to investigate the effects of somatic cell counts (SCC), differential SCC (macrophage (MAC), lymphocyte (LYM) and polymorphonuclear leukocytes (PMN)), number and stage lactation on milk composition in camel and cow milk. Camel milk appeared to contain significantly (P

Objective: To determine whether global reduction of CD68 (cluster differentiation) macrophages impacts the development experimental pulmonary arterial hypertension (PAH) and this affects balance pro- anti-inflammatory within lung. Additionally, to there is evidence an altered macrophage polarization in patients with PAH. Approach Results: Macrophage was induced mice via doxycycline-induced CD68...