نتایج جستجو برای: lch

تعداد نتایج: 667  

2015
Maliheh Khoddami Seyed Alireza Nadji Paria Dehghanian Mahsa Vahdatinia Ahmad Reza Shamshiri

BACKGROUND Langerhans cell histiocytosis (LCH) is a rare histiocytic proliferation of unknown etiology. It is characterized by granuloma-like proliferation of Langerhans-type dendritic cells and mainly affects young children. Although multiple investigators have suggested the possible role of viruses, such as Epstein-Barr virus (EBV), human herpesvirus-6 (HHV-6), Herpes simplex virus (HSV) type...

Journal: :Acta otorrinolaringologica espanola 2001
F P García-Ortega M J Carcasés Ortiz S Martínez Reig M C Beviá González R Durán J R Malluguiza Calvo

Langerhans's cell histiocytosis (LCH) is an uncommon disease characterized by an accumulation of abnormal histiocytes, together lymphocytes and eosinophils in various organs and tissues. The head and neck are frequent sites of initial presentation. We present two cases of LCH with otorhinolaryngologic symptoms. Current recommendations for diagnosis, evaluation and treatment of LCH are also disc...

Journal: :Environmental Health Perspectives 1997
Brigitte Senechal Gaelle Elain Eric Jeziorski Virginie Grondin Francis Jaubert Kheira Beldjord Arielle Lellouch Christophe Glorion Michel Zerah Mohammed Barkaoui Liliane Boccon-Gibod Patrice Josset Marianne Debré Frederic Geissmann

Langerhans cell histiocytosis (LCH) is a rare clonal granulomatous disease that affects mainly children. LCH can involve various tissues such as bone, skin, lung, bone marrow, lymph nodes, and the central nervous system, and is frequently responsible for functional sequelae. The pathophysiology of LCH is unclear, but the uncontrolled proliferation of Langerhans cells (LCs) is believed to be the...

2012
Anubhav Garg Pramod Kumar

Langerhans cell histiocytosis (LCH), is a rare disorder, clinically presents with heterogeneous manifestations, and has an unpredictable outcome. Commonly seen in infancy or early childhood, the disorder is characterized by proliferation of abnormal and clonal Langerhans cell in skin, bone, lymph nodes, lungs, liver, spleen, and bone marrow. Occurrence of LCH in adults is rare. Here, we report ...

Journal: :Journal of Cutaneous Pathology 2021

Background Pyogenic granuloma (PG) is a lesion characterized by the proliferation of blood vessels, commonly affecting skin and mouth. We aimed to compare clinical, microscopic, immunohistochemical features two types oral PG: lobular capillary hemangioma (LCH) non-LCH (NLCH). Methods Epidemiological clinical data from 2000 2018 were collected archives our institution, histopathological sections...

Journal: :BMJ case reports 2011
Andleeb Abrari Vandana Bakshi

1 of 2 DESCRIPTION The manifestations of Langerhans cell histiocytosis (LCH) are legion in both local and systemic variants. About 15–61% patients with LCH have otologic involvement; this manifestation is more frequent in children with multisystem disease and a primary manifestation in 5–25% of patients. Among otologic lesions, solitary external ear LCH, as the only site of clinically non-progr...

2016
Kaixuan Zeng Zhe Wang Koichi Ohshima Yixiong Liu Weichen Zhang Lu Wang Linni Fan Mingyang Li Xia Li Yingmei Wang Zhou Yu Qingguo Yan Shuangping Guo Jie Wei Ying Guo

Langerhans cell histiocytosis (LCH) is a neoplasm of myeloid origin characterized by a clonal proliferation of CD1a(+)/CD207(+) dendritic cells. Recurrent BRAF V600E mutation has been reported in LCH. In the present report, we confirm the feasibility of the high-specificity monoclonal antibody VE1 for detecting BRAF V600E mutation in 36/97 (37.1%) retrospectively enrolled patients with LCH; con...

2015
JJ LI J FAN H LI RM JIN

Objective: To explore the clinical characteristics of therapy-related acute promyelocytic leukaemia (t-APL) after Langerhans cell histiocytosis (LCH) in a paediatric patient. Method: The clinical manifestations and laboratory findings of a rare paediatric case were analysed and relevant literatures were reviewed. Result: A paediatric patient with LCH who had completed the whole chemotherapy was...

Journal: :Journal of Korean Neurosurgical Society 2016
Ming Zhu Bing-Bing Yu Ji-Liang Zhai Gang Sun

Langerhans cell histiocytosis (LCH) is a rare disorder histologically characterized by the proliferation of Langerhans cells. Here we present the case of a 13-year-old girl with LCH wherein CT and MRI results led us to an initially incorrect diagnosis of meningioma. The diagnosis was corrected to LCH based on pathology findings. An intracranial mass was found mainly in the dura mater, with thic...

2017
Asmaa Gaber Abdou Doha MaherTaie

Langerhans cell histiocytosis (LCH) is a rare disease characterized by a proliferation of cells that show immunophenotypic and ultrastructural similarities with antigen-presenting Langerhans cells of mucosal sites and skin. LCH in adults is rare, and there are still many undiagnosed/misdiagnosed patients. We describe LCH involvement of the perianal region of a 33-year-old male with a previous h...

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