نتایج جستجو برای: lactogenesis

تعداد نتایج: 193  

2016
Ognian C. Ikonomov Diego Sbrissa Khortnal Delvecchio James A. Rillema Assia Shisheva

Systemic deficiency of PIKfyve, the evolutionarily conserved phosphoinositide kinase synthesizing cellular PtdIns5P and PtdIns(3,5)P2 and implicated in insulin signaling, causes early embryonic death in mice. In contrast, mice with muscle-specific Pikfyve disruption have normal lifespan but exhibit early-age whole-body glucose intolerance and muscle insulin resistance, thus establishing the key...

2016
Samantha R. Weaver Justin C. Bohrer Allan S. Prichard Paola K. Perez Liana J. Streckenbach Jake M. Olson Mark E. Cook Laura L. Hernandez

Obesity is an inflammatory state associated with delayed lactogenesis stage II and altered mammary gland morphology. Serotonin mediates inflammation and mammary gland involution. The objective of this study was to determine if a genetic deficiency of tryptophan hydroxylase 1, the rate-limiting enzyme in peripheral serotonin synthesis, would result in an improved ability to lactate in dams fed a...

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