The study is aimed to assess the compatibility of bilberry leaf powder extract (BLPE) with six excipients selected for sustained-release (SR) tablet formulation. BLPE was obtained addition L-arginine and Myo-inositol as carriers. Thermogravimetric (TG-DTG) analysis Fourier-transform infrared spectroscopy (FTIR), supported by Pearson correlation analysis, were applied detect possible interaction...

The uniform and smaller-sized (~3 ?m) LiNi0.8Co0.1Mn0.1O2 (SNCM) particles are prepared via a fast nucleation process of oxalate co-precipitation, followed by two-step calcination procedure. It is found that the vigorous agitation enables us to produce nuclei having size which then grow into micron-particles in less than few minutes. impacts solution pH, precipitation time, temperature, surface...

Objective: The present study was an attempt to develop alternative dosage form for the existing conventional oral, parenteral proton pump inhibitor (PPI) as transdermal patches treating peptic ulcers. Methods: Transdermal of PPI were prepared using HPMC E5 with PVP K 30 and Eudragit L100 polymers in different ratios by a solvent evaporation method. All formulated subjected various evaluation pa...

Rats with chronic heart failure (CHF) develop increased myogenic constriction in mesenteric resistance arteries. Here we investigated increased myogenic constriction in relation to alterations in EDHF- and NO-mediated dilatation in CHF-rats. Male Spraque-Dawley rats were subjected to myocardial-infarction or sham-surgery. At 9-10 weeks after surgery, isolated mesenteric artery ring preparations...

Software security is a major concern for vendors, consumers, and regulators since attackers that exploit vulnerabilities can cause substantial damages. When vulnerabilities are discovered after the software has been sold to consumers, the firms face a dilemma. A policy of disclosing vulnerabilities and issuing updates protects only the consumers who install updates, while the disclosure itself ...

Microwells fabricated from poly-L-lactic acid (PLLA) were evaluated for their application as an oral drug delivery system using the amorphous sodium salt of furosemide (ASSF) as a model drug. Hot embossing of PLLA resulted in fabrication of microwells with an inner diameter of 240 μm and a height of 100 μm. The microwells were filled with ASSF using a modified screen printing technique, followe...

OBJECTIVE Development of liposomal mucoadhesive drug delivery system, which is able to improve the bioavailability of poorly absorbed oral drugs by prolonging their gastric and intestinal residence time, through facilitating the intimate contact of the delivery system with the absorption membrane. MATERIALS AND METHODS Liposomes containing model drug atenolol were prepared by the modified eth...