Thrombin-Mediated Endothelial Activation Kruppel-Like Factor 2 Inhibits Protease Activated Receptor-1 Expression and Print ISSN: 1079-5642. Online ISSN: 1524-4636 Copyright © 2006 American Heart Association, Inc. All rights reserved. Greenville Avenue, Dallas, TX 75231 is published by the American Heart Association, 7272 Arteriosclerosis, Thrombosis, and Vascular Biology doi: 10.1161/01.ATV.000...

Source and Description: Cos39 cosmid was obtained from a chromosome 22-enriched library and its partial sequence revealed a zinc finger motif of the Kruppel type (1). A 1 kb Sau3A I fragment derived from Cos39 and giving a positive signal when hybridized with a poly(dC-dA)-poly(dG-dT) probe was subcloned into the BamHI site of pBluescript SK+ (Stratagene). Partial sequence of this subclone reve...

the satellite cells. Contaminating CD45+/Mac-1+/Sca-1+ cells were subsequently removed by MACS cell separation. Cell cycle analysis revealed that over 80% of the resulting myogenic cell population was in G0, indicating a high proportion of quiescent cells in the isolated population. RT-PCR analysis showed that the expression of three Kruppel-like factors (Klf) was increased in quiescent satelli...

The cellular events that lead to terminal erythroid differentiation rely on the controlled interplay of extra- and intracellular regulatory factors. Their downstream effects are highly coordinated and result in the structural/morphologic and metabolic changes that uniquely characterize a maturing red blood cell. Erythroid Krüppel-like factor (EKLF/KLF1) is one of a very small number of intrinsi...