Astaxanthin and tocotrienols, known as antioxidants derived from natural compounds shown to have anti-inflammatory properties. This study aims investigate the effects of a combination astaxanthin extracted Hematococcus pluvialis microalga palm tocotrienols rich-fraction (TRF) on inflammatory reaction in lipopolysaccharide (LPS)-stimulated mouse RAW 264.7 macrophages cells. MTT assay was used te...

The emergence of antibiotics resistances become an alarming situation due to the resurgence cases. Scientific community explore therapeutics alternatives, including essentials oils and their combination with antibiotics. designed study aimed evaluate combined effects from Drypetes Gosswelleri, Echinops giganteus, Melaleuca leucadendron against strains implicated in infectious deseases. antibact...

The use of targeted inhibitors has shown promise as an effective approach in cancer therapy. However, therapies based only on one drug, such 17-allylamino-17-demethoxygeldanamycin (17-AAG), have limited success, partly because cells engage alternate pathways for survival and proliferation. In the present study, we evaluated whether dehydroxymethylepoxyquinomicin (DHMEQ), a nuclear factor ?B (NF...

(1) Background: Temozolomide (TMZ), an oral alkylating agent, is used to treat malignant gliomas and other difficult-to-treat tumors. TMZ can enter the cerebrospinal fluid p.o. (per os) does not need hepatic metabolism for activation of its use as a standard chemotherapeutic regimen after surgical resection glioma brain. However, prognosis remains poor most patients, survival rate still unsatis...

Although cisplatin and pemetrexed are key drugs in the treatment of malignant pleural mesothelioma, their drug-drug interactions, cross-resistance and resistance mechanisms in malignant pleural mesothelioma are not well understood. In the present study, the interaction of these 2 agents was determined by clonogenic assays followed by isobologram a...

The aquatic ecotoxicity of chemicals involved in the manufacturing process of thin film transistor liquid crystal displays was assessed with a battery of four selected acute toxicity bioassays. We focused on tetramethylammonium hydroxide (TMAH, CAS No. 75-59-2), a widely utilized etchant. The toxicity of TMAH was low when tested in the 72 h-algal growth inhibition test (Pseudokirchneriellia sub...

Although monotherapy in epilepsy treatment is frequently advocated, this is not based on studies with equal drug loads. This study was performed to investigate the experimental background of polytherapy with standardized drug loads. Dose-dependent effects on grip strength, accelerod performance, and spontaneous behavior of rats was used to study the effect of combining valproate and ethosuximid...