The linear logistical isobologram is a commonly used and powerful graphical and statistical tool for analyzing the combined effects of simple chemical mixtures. In this paper a nonlinear isobologram model is proposed to analyze the joint action of chemical mixtures for quantitative dose-response relationships. This nonlinear isobologram model incorporates two additional new parameters, Ymin and...

New concepts in radiation oncology are based on the concept that combinations of irradiation and molecular targeted drugs can yield synergistic or at least additive effects. Up to now the combination of two treatment modalities has been tested in almost all cases. Similar to conventional anti-cancer agents, the efficacy of targeted approaches is also subject to predefined resistance mechanisms....

We studied the antioxidant activities of the essential oils of Zataria multiflora Boiss. (ZEO) and Bunium persicum (Boiss.) B. Fedtsch (BEO) in mixed form on linseed oil using (DPPH•), ­(­ABTS•+), H2O2 scavenging, and reducing power assays. After calculation of IC50 for ZEO and BEO separately, interactions of the essential oils were investigated at the form of mixture and the results were given...

Isobologram and combination index (CI) analyses are the two most popular methods for evaluating drug interactions in combination cancer chemotherapy. As the commonly used CI-based software program uses linear regression, our first objective was to evaluate the effects of logarithmic data transformation on data analysis and conclusions. Monte-Carlo simulations were conducted with experimentally ...

The need for drug combinations to treat visceral leishmaniasis (VL) arose because of resistance to antimonials, the toxicity of current treatments and the length of the course of therapy. Calcium channel blockers (CCBs) have shown anti-leishmanial activity; therefore their use in combination with standard drugs could provide new alternatives for the treatment of VL. In this work, in vitro isobo...

we studied the antioxidant activities of the essential oils of zataria multiflora boiss. (zeo) and bunium persicum (boiss.) b. fedtsch (beo) in mixed form on linseed oil using (dpph•), ­(­abts•+), h2o2 scavenging, and reducing power assays. after calculation of ic50 for zeo and beo separately, interactions of the essential oils were investigated at the form of mixture and the results were given...

Inflammation is the reaction of immune system to an external or internal aggression organism. The symptoms (redness, edema, heat and pain) are secondary increase in vascular permeability. hydroethanolic extract has anti-inflammatory properties vitro. aim was examine analgesic activities extracts alone combination. activity studied using carragenan-induced paw edema type interactions between two...