The interior of the eye, or uvea, is a site of immune privilege where certain immune responses are attenuated or completely excluded to protect non-regenerating tissues essential for vision. One consequence of this immunoregulation is compromised immune mediated elimination of intraocular tumors. For example, certain murine tumor cell lines which are rejected by host immune responses when trans...

purpose: to describe the biometric changes and their effect on intraocular lens (iol) power calculation after trabeculectomy and to compare the accuracy of four formulas namely srk/ii, srk/t, holladay and hoffer q for iol power calculation in these patients. methods: thirty-four eyes of 31 glaucoma patients who were scheduled for primary trabeculectomy were enrolled. a non-contact biometry devi...

BACKGROUND Myofibroblastoma is a benign tumor composed of spindle cells and bands of hyalinized collagen. Intraocular myofibroblastoma in infancy is rarely encountered. CASE PRESENTATION The present study reports the case of a 4-month-old female baby with intraocular myofibroblastoma. She was suspected as corneal perforation due to the rupture of a corneal neoplasm in the right eye. The anter...

Purpose Intraocular medulloepithelioma (IM), the second most common primary neuroepithelial tumor of the eye, can lead to blindness in the affected eye and in rare cases, is deadly. Intraocular medulloepithelioma lacks targetable biomarkers for potential pharmacologic therapy. The purpose of this study was to identify actionable, tumor-specific proteins for potential diagnostic or therapeutic s...

introduction: ophthalmic plaque radiotherapy using i-125 radioactive seeds in removable episcleral plaques is often used in management of ophthalmic tumors. radioactive seeds are fixed in a gold bowl-shaped plaque and the plaque is sutured to the scleral surface corresponding to the base of the intraocular tumor. this treatment allows for a localized radiation dose delivery to the tumor with a ...

PURPOSE To describe clinical, optical coherence tomography (OCT) and fundus autofluorescence (FAF) findings in patients with intraocular tumors and determine if OCT and FAF could be helpful in the differential diagnosis and management of different choroidal tumors. METHODS Forty-nine patients with untreated, macular, midperipheral, and extrapapillary intraocular tumors were included. All pati...

A series of investigations was employed to determine if metastases of intraocular melanomas could be induced by experimental manipulations. Syngeneic B16F10 melanoma cells transplanted intracamerally into C57BL/6 mice produced progressively growing intraocular tumors, yet formed only occasional pulmonary metastases. Neither enucleation nor mechanical manipulation of the melanoma-containing eye ...

Ags expressed at immune privileged sites and other peripheral tissues are able to induce T cell tolerance. In this study, we analyzed whether tolerance toward an intraocular tumor expressing a highly immunogenic CTL epitope is maintained, broken, or reverted into immunity in the event the anatomical integrity of the eye is lost. Inoculation of tumor cells into the anterior chamber of the eye of...

BACKGROUND This study retrospectively analyzed outcomes for patients undergoing gamma knife radiosurgery (GKR) for uveal melanoma (UM) and intraocular metastases. METHODS Patients who underwent GKR for UM or intraocular metastases between 1/1/1990 and 6/1/2015 at Mayo Clinic, Rochester, MN, USA, were retrospectively analyzed. RESULTS Eleven patients (11 eyes) had UM while seven patients (7 ...