OBJECTIVE Laminar shear stress is atheroprotective for endothelial cells (ECs), whereas nonlaminar, disturbed, or oscillatory shear stress correlates with development of atherosclerosis and neointimal hyperplasia. The effects of orbital and laminar shear stress on EC morphology, proliferation, and apoptosis were compared. METHODS ECs were exposed to orbital shear stress with an orbital shaker...

Background—Atherosclerotic lesions are predominantly observed in curved arteries and near side branches, where low or oscillatory shear stress patterns occur, suggesting a causal connection. However, the effect of shear stress on plaque vulnerability is unknown because the lack of an appropriate in vivo model precludes cause-effect studies. Methods and Results—We developed a perivascular shear ...

a 5th order shear deformation theory considering transverse shear deformation effect as well as transverse normal strain deformation effect is presented for static flexure   analysis of simply supported isotropic plate. the assumed displacement field accounts for non-linear variation of in-plane displacements as well as transverse displacement through the plate thickness. the condition of zero ...

A cost-effective approach to improve the physical and mechanical properties of carbon fiber reinforced polymer (CFRP) prepreg composites, where electrospun multiwalled nanotubes (MWCNTs)/epoxy nanofibers were synthesized incorporated in between layers conventional CFRP composite has been presented. MWCNT-aligned epoxy successfully produced by an optimized electrospinning process. Nanofibers dep...

this paper presents a novel formulation and numerical solutions for adhesively bonded composite joints with non-linear (softening) adhesive behaviour. the presented approach has the capability of choosing arbitrary loadings and boundary conditions. in this model adherends are orthotropic laminates that obey classical lamination theory. the stacking sequences can be either symmetric or asymmetri...

This study aimed to investigate the suitability of interlaminar shear (ILS) testing method for veneer-based composites. The ILS is an established composite materials as a qualitative evaluation adhesion within composite. applicability this veneer based composites enables simple statement on individual layers. complements existing wood-based material tests that focus bonding, using significantly...

Abstract This research proposes a novel model targeting expansive bedrock by combining an elastoplastic considering electro-chemo-mechanical phenomena with the Cam-clay model, based on considerations of cementation and its degradation owing to plastic deformation. Additionally, tunnel excavation swelling analyses are demonstrated incorporating proposed into finite element analysis code. Specifi...

We have shown that leukocytes retract their pseudopods and detach from substrates after exposure to physiological fluid shear stresses ( approximately 1.5 dyn/cm(2)). In inflammation, however, pseudopod projection during spreading and firm adhesion on endothelium is observed even in microvessels with normal blood flow and fluid shear stresses. Thus, we examined mechanisms that may serve to regu...

Matrix metalloproteinase (MMP)-1, 2, with their endogenous inhibitors, tissue inhibitor of metalloproteinase (TIMP)-1, 2 are critical for extracellular matrix remodeling in human periodontal ligament (PDL) and their expression are sensitive to mechanical stresses. Shear stress as the main type of mechanical stress in tooth movement is involved in matrix turnover. However, how shear stress regul...