نتایج جستجو برای: inos protein

تعداد نتایج: 1236459  

Journal: :American journal of physiology. Heart and circulatory physiology 2010
Philipp Heusch Stephanie Aker Kerstin Boengler Elisabeth Deindl Anita van de Sand Kristina Klein Tienush Rassaf Ina Konietzka Adrian Sewell Sara Menazza Marcella Canton Gerd Heusch Fabio Di Lisa Rainer Schulz

Our objective was to address the balance of inducible nitric oxide (NO) synthase (iNOS) and arginase and their contribution to contractile dysfunction in heart failure (HF). Excessive NO formation is thought to contribute to contractile dysfunction; in macrophages, increased iNOS expression is associated with increased arginase expression, which competes with iNOS for arginine. With substrate l...

Journal: :The European respiratory journal 2009
A S Naura R Datta C P Hans M Zerfaoui B M Rezk Y Errami M Oumouna K Matrougui A H Boulares

Inducible nitric oxide synthase (iNOS) inhibition was recently shown to exert no effect on allergen challenge in human asthma, raising serious concerns about the role of the protein in the disease. The present study investigated the role of iNOS in ovalbumin-induced eosinophilia from the perspective of its relationship with poly(ADP-ribose) polymerase-1 (PARP-1) and oxidative DNA damage. A mous...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2000
K McMillan M Adler D S Auld J J Baldwin E Blasko L J Browne D Chelsky D Davey R E Dolle K A Eagen S Erickson R I Feldman C B Glaser C Mallari M M Morrissey M H Ohlmeyer G Pan J F Parkinson G B Phillips M A Polokoff N H Sigal R Vergona M Whitlow T A Young J J Devlin

Potent and selective inhibitors of inducible nitric oxide synthase (iNOS) (EC ) were identified in an encoded combinatorial chemical library that blocked human iNOS dimerization, and thereby NO production. In a cell-based iNOS assay (A-172 astrocytoma cells) the inhibitors had low-nanomolar IC(50) values and thus were >1,000-fold more potent than the substrate-based direct iNOS inhibitors 1400W...

Journal: :Circulation research 2007
Ping Zhang Xin Xu Xinli Hu Elza D van Deel Guangshuo Zhu Yingjie Chen

Inducible nitric oxide synthase (iNOS) protein is expressed in cardiac myocytes of patients and experimental animals with congestive heart failure (CHF). Here we show that iNOS expression plays a role in pressure overload-induced myocardial chamber dilation and hypertrophy. In wild-type mice, chronic transverse aortic constriction (TAC) resulted in myocardial iNOS expression, cardiac hypertroph...

Journal: :Shock 2003
Joy L Collins Yoram Vodovotz Christian Hierholzer Raphael T Villavicencio Shubing Liu Sean Alber David Gallo Donna B Stolz Simon C Watkins Anthony Godfrey William Gooding Edward Kelly Andrew B Peitzman Timothy R Billiar

It has been previously shown that the inducible nitric oxide (NO) synthase (iNOS; NOS-2) is elevated after hemorrhage, and that iNOS-derived NO participates in the upregulation of inflammation as well as lung and liver injury postresuscitation from shock. The purpose of this study was to elucidate the time course of iNOS mRNA expression, as well as the cellular and subcellular localization of i...

2013
Luyi Mao Qiongjie Zhou Shufeng Zhou Rhonda R. Wilbur Xiaotian Li

OBJECTIVES To investigate potential roles of inducible nitric oxide synthase (iNOS) and apolipoprotein (apoE) in inflammation and apoptosis promoting pathological changes in preeclampsia in pregnant mice with apoE and/or iNOS knock out. METHODS B6.129 mice were crossed to produce WT, apoE(-/-), apoE(+/-), iNOS(-/-), iNOS(+/-) and apoE(-/-)iNOS(-/-) groups. Variants were confirmed by PCR. Seru...

2002
Takashi Miyauchi Seiji Maeda Motoyuki Iemitsu Tsutomu Kobayashi Yoshito Kumagai Iwao Yamaguchi Mitsuo Matsuda

Nitric oxide (NO) is produced in the vascular endothelium and is a potent vasodilator substance that participates in the regulation of local vascular tone. Exercise causes peculiar changes in systemic and regional blood flow, i.e. an increase of systemic blood flow and a redistribution of local tissue blood flow, by which the blood flow is greatly increased in the working muscles, whereas it is...

Journal: :Journal of virology 2006
Aitor G Granja Prado Sabina María L Salas Manuel Fresno Yolanda Revilla

Uncontrolled generation of nitric oxide (NO) by inducible nitric-oxide synthase (iNOS) can cause damage to host cells and inflammation, two undesirable events for virus spreading. African swine fever virus (ASFV) infection regulates iNOS-induced gene expression through the synthesis of the A238L virus protein. We here explored the role of A238L, an NF-kappaB and NFAT inhibitor, in the regulatio...

Journal: :The American journal of physiology 1999
Hong Ling Charles Edelstein Patricia Gengaro Xianhong Meng Scott Lucia Mladen Knotek Adisorn Wangsiripaisan Yeuxian Shi Robert Schrier

Renal ischemia-reperfusion (I/R) injury was investigated in inducible nitric oxide synthase (iNOS) knockout mice. After a 26-min bilateral renal pedicle clamp, serum creatinine concentrations (in mg/dl) in wild-type mice after a 24-h reperfusion were 0.25 ± 0.03 in sham-operated controls and 2.3 ± 0.38 in ischemic mice ( P < 0.01); after 48 h, concentrations (in mg/dl) were 0.25 ± 0.03 in contr...

Journal: :American journal of physiology. Heart and circulatory physiology 2007
Rachel J Jones David Jourd'heuil John C Salerno Susan M E Smith Harold A Singer

Nitric oxide synthase (NOS) expression is regulated transcriptionally in response to cytokine induction and posttranslationally by palmitoylation and trafficking into perinuclear aggresome-like structures. We investigated the effects of multifunctional calcium/calmodulin-dependent protein kinase II protein kinase (CaMKII) on inducible NOS (iNOS) trafficking in cultured rat aortic vascular smoot...

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