Dopamine secreted from hypophysial hypothalamic neurons is a principal inhibitory regulator of pituitary hormone secretion. Mice with a disrupted D2 dopamine receptor gene had chronic hyperprolactinemia and developed anterior lobe lactotroph hyperplasia without evidence of adenomatous transformation. Unexpectedly, the mutant mice had no hyperplasia of the intermediate lobe melanotrophs. Aged fe...

The present study examines the role of cerebroventricular administered (IIIrd ventricle) galanin on LHRH and LH release in adult and immature male rats. In both age groups, galanin stimulated LHRH synthesis and release from the hypothalamus, leading to a higher release of pituitary LH which in turn increased plasma LH levels. Galantide, a galanin receptor blocker, on the other hand, drastically...

Recent data indicate that there is an interaction between psychostimulant drugs and gonadal hormones. Mello and colleagues (1994) have collected convincing evidence suggesting that psychomotor drugs can disrupt or alter ovarian and hypophysial hormonal function. The reverse of this also appears to be true; that is, these hormones can affect the physiological and behavioral response to cocaine (...

tumorigenesis by modifying endocrine status, possibly by in terfering with some aspect of ovarian or pituitary function. The inhibitory nature of either a deprival or an excess of ovarian and/or hypophysial hormone(s) on mammary carcinogenesis is well documented (4). However, it has been reported that retinyl acetate inhibits mammary carcinogenesis to a greater extent in the presence of the inh...

TRH and CRH are secreted into the hypophysial portal circulation by hypophysiotropic neurons located in parvicellular subdivisions of the hypothalamic paraventricular nucleus (PVH). Recently these anatomical compartments of the PVH have been shown to contain large numbers of glutamatergic neurons expressing type 2 vesicular glutamate transporter (VGLUT2). In this report we presented dual-label ...

There is worldwide interest in buffalo as an animal for meeting the growing demands of meat, milk and work in the developing countries. One of the major constraints to full exploitation of the productive potential of buffalo has been its inherently low reproductive efficiency as reflected by late maturity, poor expression of oestrus, silent oestrus, irregular oestrous cyclicity, seasonality in ...