Sinus histiocytosis with massive lymphadenopathy or Rosai-Dorfman disease (RDD) is a reactive condition of unknown etiology, characterised by a proliferation of histiocytes exhibiting emperipolesis of lymphocytes and plasma cells. It usually presents as bilateral painless cervical lymphadenopathy. Extranodal RDD without nodal disease is seen in 23% of the cases. Intracranial RDD occurs in less ...

Virus associated hemophagocytic syndrome (VAHS) are a heterogeneous group of disorders in which viral infection is associated with a proliferation of hemophagocytic histiocytes through the reticuloendothelial system. We report the case of a 21-year-old Korean man who presented to us with high fever, marked hepatosplenomegaly, severe hepatic dysfunction, coagulopathy, pancytopenia and marked pan...

A 50-year-old man with a 6-month history of arthralgias, recurrent pericardial and pleural effusions presented to the nephrology clinic with uncontrolled hypertension and elevated creatinine. No proteinuria or hematuria was noted. Computed tomography (CT) scan of the abdomen showed a hypodense tissue encasing both kidneys (Figure 1A). Tissue biopsy revealed a fibroproliferative process, dense f...

Dear Dr. Bedrossian: I would like to offer an explanation as to how the nodules of so-called nodular histiocytic hyperplasia (NHH) form in some specimens of pleural, peritoneal, and pericardial fluid. Such nodules were well-illustrated by Drs. Choi and Song in their recently published article in Diagnostic Cytopathology.1 They demonstrated that these nodules are composed of compact aggregates o...

In the human lymphoreticular system, the alpha and beta subunits of S-100 protein are found in ordinary monocyte-macrophages and non-phagocytic histiocytes such as Langerhans cells and interdigitating reticulum cells, respectively. The beta subunit is also present in some CD8+ T cells. In the present study, we investigated the ontogeny of these histiocytes and lymphocytes in humans. Yolk sacs a...

AIMS Strong thyroglobulin immunoreactivity within sinus histiocytes in a lymph node draining a papillary thyroid carcinoma was observed in a recent case. This prompted the investigation of whether thyroglobulin immunoreactivity is common in regional lymph nodes in cases of thyroid malignancy. METHODS Eighty seven lymph nodes were studied from 21 cases of thyroid malignancy. These comprised pa...

Rosai-Dorfman disease is a rare, idiopathic, benign, and self-limiting histiocytic proliferative disorder. A 26-year-old man presented with a single massive cutaneous nodule (reaching 30 cm in diameter) on the left shoulder and back for 15 months. The routine hematological and biochemical tests were normal. Magnetic resonance scanning showed the lesion involved the skin, subcutaneous tissue, an...

A 33 year old man presented with three months of persistent hoarseness with no preceding upper respiratory tract infection. He was otherwise a healthy young policeman and he was a non-smoker. A benign looking polyp was discovered on microlaryngoscopic examination at the anterior end of the left vocal cord adjacent to the anterior commissure. This was biopsied and subsequent histological examina...

Case presentation: Boy, 7 years old. Born at term, with no history of consanguinity or complications. Previously healthy patient. Child a Attention Deficit and Hyperactivity Disorder, adequate neuropsychomotor development. He evolved spastic paraparesis, frequent falls, enuresis, focal epilepsy, reduced strength in the lower limbs cutaneous plantar reflex extension. In investigation, neuraxial ...