the role of endogenous histamine and h1, h2 and h3 central receptors on food intake in broiler chickenswas investigated. for this purpose, a probe was used to manipulate the concentration of endogenoushistamine by intracerebroventricular (icv) injection of thioperamide, an h3 receptor antagonist, and r-α-methylhistamine, an h3 receptor agonist and subsequently the effects of brain histaminergic...

Since one of us, Takehiko Watanabe (TW), elucidated the location and distribution of the histaminergic neuron system in the brain with antibody raised against L-histidine decarboxylase (a histamine-forming enzyme, HDC) as a marker in 1984 and came to Tohoku University School of Medicine in Sendai, we have been collaborating on the functions of this neuron system by using pharmacological agents,...

Heart of England NHS Foundation Trust, Birmingham, UK School of Life and Health Sciences, Aston Brain Centre, Aston University, Birmingham, UK Children’s Epilepsy Surgery Programme, The Birmingham Children’s Hospital NHS Foundation Trust, Birmingham, UK Department of Neuropsychiatry, Birmingham and Solihull Mental Health NHS Foundation Trust, Birmingham, UK Sobell Department of Motor Neuroscien...

Background. Itch can be transmitted by two parallel pathways, histaminergic and nonhistaminergic. Histaminergic itch is a subgroup of mechano-insensitive C-fibers, while nonhistaminergic polymodal C-fibers. Experimental models are used to study pruritus: histamine for the antagonizing H1-receptors, BAM8-22 cowhage activating Mas-related G protein-coupled receptors protease-activated receptors, ...

Histaminergic fibers are present in the molecular and granular layers of the cerebellum and have a high density in the vermis and flocullus. Evidence supports that the cerebellar histaminergic system is involved in memory consolidation. Our recent study showed that histamine injections facilitate the retention of an inhibitory avoidance task, which was abolished by pretreatment with an H2 recep...

Objective The aim of this study was to evaluate the influence of adalimumab on expression profile of genes associated with the histaminergic system in Normal Human Dermal Fibroblast (NHDF) cells stimulated with 8.00 μg/ml of adalimumab and the identification of miRNAs regulating these genes' expression. Methods NHDFs were cultured with or without the presence of adalimumab for 2, 8, and 24 ho...

Retrieval represents a dynamic process that may require neuromodulatory signaling. Here, we report that the integrity of the brain histaminergic system is necessary for retrieval of inhibitory avoidance (IA) memory, because rats depleted of histamine through lateral ventricle injections of α-fluoromethylhistidine (a-FMHis), a suicide inhibitor of histidine decarboxylase, displayed impaired IA m...