The potential of human embryonic stem (hES) cells for therapeutic purposes became immediately clear after their derivation by Thomson’s group in 1998. It was also clear, though, that their origin represented their main limitation. The ethical and legislative issues challenging hES cell-based research have produced a ‘selective pressure’ in response to which a new type of stem cells has stemmed:...

background: developmental dysplasia of hip (ddh) is a common childhood disorder, and ultrasonography examination is routinely used for screening purposes. in this study, we aimed to evaluate a modified combined static and dynamic   ultrasound technique for the detection of ddh and to compare with the results of static and dynamic ultrasound techniques.       methods: in this cross-sectional stu...

OBJECTIVE To evaluate the bleeding of the femoral head on hip osteoarthritis in patients who underwent total hip arthroplasty. METHODS One hundred and three hips affected by primary hip osteoarthritis were evaluated. After surgical dislocation, the femoral head was divided into four quadrants, and micro perforations were made in order to observe and assess the presence of bleeding, as early t...

Tantalum rod implantation with vascularized iliac grafting has been reported to be an effective method for the treatment of young patients with osteonecrosis of the femoral head (ONFH) to avert the need for total hip arthroplasty (THA). However, there have been unsatisfactory success rates for end-stage ONFH. The authors describe a modified technique using bone marrow mesenchymal stem cells (BM...

Metal-on-metal total hip replacement has been targeted at younger patients with anticipated long-term survival, but the effect of the production of metal ions is a concern because of their possible toxicity to cells. We have reviewed the results of the use of the Ultima hybrid metal-on-metal total hip replacement, with a cemented polished tapered femoral component with a 28 mm diameter and a co...

BACKGROUND Acetabular dysplasia is a major predisposing factor for development of hip osteoarthritis (OA), and may result from alterations to chondrolabral loading. Subject-specific finite element (FE) modeling can be used to evaluate chondrolabral mechanics in the dysplastic hip, thereby providing insight into mechanics that precede OA. OBJECTIVE To evaluate chondrolabral contact mechanics a...

OBJECTIVE The objective of this study was to investigate a possible relation between congenital hip dysplasia and acetabular retroversion and to explore the eventual influence of the latter in the surgical decision for periacetabular osteotomy. MATERIALS AND METHODS We assessed the classical morphological characteristics of both hips, with an additional newly described retroversion index. The...

Three to eight percent of female carriers of Duchenne muscular dystrophy (DMD) develop dystrophic symptoms ranging from mild muscle weakness to a rapidly progressive DMD-like muscular dystrophy due to skewed inactivation of X chromosomes during early development. Here, we generated human induced pluripotent stem cells (hiPSCs) from a manifesting female carrier using retroviral or Sendai viral (...

Our aim is to analyse the clinical outcome of a series of patients affected by avascular necrosis of the femoral head and treated with core-decompression technique and autologous stromal cells of the bone marrow.We enrolled in our study 29 patients with 31 hips in total affected by avascular necrosis of the femoral head. The clinical and radiological outcome has been assessed through self-admin...