Background Previously, we have demonstrated the cardioprotective effect of interleukin (IL)-11 in animal models of acute coronary syndrome. In this study, we sought to evaluate its cardioprotective potential during prolonged hypothermic global ischemia and subsequent reperfusion using a rat heart donor model. Methods IL-11 was administered intravenously 10 minutes before harvesting the rat he...

background: corn silk (cs) is widely used in iranian traditional medicine and feijoa sellowiana(fs) is a native plant widespread in the southern parts of iran. the aim of the present study was to assess renal protective activities of cs and fs against dosage induced injury by ecstasy (mdma) using insitu rat renal perfusion (irrp) system.methods: hydro-alcoholic extract of cs and fs (10, 20, 40 ...

Ergovaline has been proposed as a toxic component of endophyte-infected tall fescue. As many of the symptoms of fescue toxicosis are a result of compromised circulation, the objective of this study was to examine the vasoconstrictive potentials of ergovaline and a more documented ergopeptine, ergotamine, using a bovine, lateral (cranial branch) saphenous vein bioassay. Segments of the cranial b...

INTRODUCTION The quality and effectiveness of myocardial protection are fundamental problems to expand the use of and consequently good outcomes of donated hearts for transplantation. OBJECTIVE The purpose of this investigation was to compare the cardioprotective effects of Krebs-Henseleit, Bretschneider-HTK, St Thomas, and Celsior solutions using a modified nonrecirculating Langendorff colum...

Experimental diabetes in the rat is associated with a well-characterized decrease in motor nerve conduction velocity (Gillon et al., 1983). In rat sciatic nerve, induction of diabetes results in marked elevation of the concentrations of glucose, sorbitol and fructose, whereas the concentration of myo-inositol is reduced (Palmano et al., 1977). Diabetic nerve malfunction may occur as a result of...

BACKGROUND While acute hyperglycemia has been shown to mitigate the beneficial effects of ischemic preconditioning, its effect on insulin-induced preconditioning remains unclear. METHODS The study was designed to test the hypothesis that acute hyperglycemia diminishes the cardioprotective effects following a 20-min pre-ischemic pre-conditioning with insulin in the isolated rat heart using the...

Isolated, isovolumic rat hearts, perfused by Krebs-Henseleit buffer at constant coronary flow rate, were used to explore the hypothesis that endogenous cardiac glutathione provides protection against myocardial dysfunction associated with short periods of ischemia. Experimental animals were depleted of cardiac glutathione to 35% of control levels by intraperitoneal injections of diethylmaleate ...

AIM Hyperglycemia is known to be associated with an increase in mortality in myocardial infarction and intensive care patients despite the fact that glucose metabolism plays a central role in myocardial protection. We studied the effect of different glucose levels (22 mM L(-1); 5.5 mM L(-1); and 0 mM L(-1)) on the contractile reserve of isolated rat atrial myocardium during and after hypoxia. ...

The ergot alkaloid ergovaline has demonstrated a persistent and sustained contractile response in several different vascular models. It was hypothesized that different alkaloids isolated from tall fescue (Lolium arundinaceum) will contribute to this contractile response differently. The objective was to compare contractile-response patterns of single additions of the ergoline alkaloids lysergic...

the effects of different concentrations of the hydroalcoholic extract of dried powdered leaves of cichorium intybus l., on ccl4-induced hepatotoxicity in vivo in rats and ccl4-induced cytotoxicity in isolated rat hepatocytes were investigated. rats received different concentrations of the extract by i.p. injection for 3 consecutive days before the injection of (3ml/kg) ccl4 (i.p.). twenty four ...