Malignant histiocytosis (MH) is a rare hematologic malignancy, especially in the first decade of life. The disease is clinically characterized by fever, hepatosplenomegaly, lymphadenopathy, pancytopenia and jaundice, and histologically by systemic proliferation of malignant histiocytes and hemophagocytosis. The prognosis is poor and often the diagnosis is not made before death. Because of ...

Pure white cell aplasia (PWCA), also known as agranulocytosis without granulopoiesis, is an uncommon condition that causes neutropenia. If linked with thymomas or medication-induced PWCA, surgical thymectomy drug cessation may be therapeutically helpful. Here we present the case of adult 18-year-old male came at The Indus Hospital and Health Network (IHHN) , Karachi in-patient department (IPD) ...

Hemophagocytic syndrome (HPS) is an uncommon hematological disorder that manifests as fever, splenomegaly, and jaundice, with hemophagocytosis in the bone marrow and other tissues pathologically. Secondary HPS is associated with malignancy and infection, especially viral infection. The prevalence of cytomegalovirus (CMV) infection in ulcerative colitis (UC) patients is approximately 16%. Nevert...

Sema Arayıcı1, Fatma Nur Sarı1, Neşe Yaralı2, Mehmet Yekta Öncel1, Gülsüm Kadıoğlu Şimşek1, Nurdan Uras1, Uğur Dilmen3 1Zekai Tahir Burak Maternity Teaching Hospital, Division of Neonatology, Ankara, Turkey 2Ankara Children’s Hematology Oncology Training and Research Hospital, Clinic of Pediatric Hematology, Ankara, Turkey 3Yıldırım Beyazıt University Faculty of Medicine, Department of Pediatri...

Hemophagocytic lymphohistiocytosis (HLH) is a rare and potentially fatal disorder characterized by abnormal activation of macrophages and occurring in many conditions in all age group. It is also characterized by hemophagocytosis in the bone marrow and in the reticuloendothelial system (RES). The underlying mechanism of acquired HLH is associated with uncontrolled inflammatory reaction which in...

To the Editor: We found interesting the article by Lupo et al. about a case of fatal measles in an immunocompetent 29-yearold woman (Fatal measles without rash in immunocompetent adult, France; http://dx.doi.org/10.3201/ eid1803.111300). Perhaps, however, the possible diagnosis of secondary hemophagocytic lymphohistiocytosis (HLH) should also have been considered in that setting. HLH is a poten...