We have evaluated the laboratory performance and clinical usefulness of the Roche fructosamine kit. As used with an Abbott ABA 100 bichromatic analyzer, the kit response varied linearly with fructosamine concentration to 5.0 mmol/L (deoxymorpholinofructose equivalents). Interbatch precision was 4.1% and 3.6% for respective fructosamine concentrations of 3.2 and 5.0 mmol/L; intrabatch precision ...

Although self monitoring of blood glucose is accepted to be effective in lowering Hb A1c levels in insulin-treated diabetic patients, any benefit in non-insulin-treated patients remains controversial. Observational studies cannot answer this question because of either patient self selection (individuals with healthier life styles chose to perform more SMBG) or physician self selection (patients...

Little is known about age-related changes in red blood cell (RBC) membrane transport and homeostasis. We investigated first whether the known large variation in plasma membrane Ca2 (PMCA) pump activity was correlated with RBC age. Glycated hemoglobin, Hb A1c, was used as a reliable age marker for normal RBCs. We found an inverse correlation between PMCA strength and Hb A1c content, indicating t...

The underlying pathophysiology of diabetes varies, but all patients share a common a metabolic derangement of carbohydrate metabolism, which causes hyperglycemia. Many patients with diabetes develop debilitating complications, ranging from retinopathy and nephropathy, to myocardial infarction and stroke. The accumulated evidence reveals that reducing an increased glucose concentration, as docum...

Perhaps diabetes is a bit like obscenity: We know it when we see obvious cases, but it is difficult to develop one definition that encompasses the entire spectrum of disease. Hyperglycemia exists on a continuum, and persons destined to develop type 2 diabetes progress along this continuum over time, from having blood glucose concentrations that are physiologic, to those in some intermediate but...

Çalışmamız, biyokimya laboratuvarında çeşitli nedenlerle saptanan numune reddini türlerine göre değerlendirmeyi amaçlamıştır. Bu çalışmada, bir eğitim ve araştırma hastanesinin yıllık süre içinde reddi nedenleri kategorize edildi. red arasında pıhtılı numune, hemolizli yetersiz fazla hatalı alınmış işlem, kap/tüp istem bulunmaktadır. sedimantasyon, hormon, koagülasyon, Hb A1c, biyokimya, kan ga...