The isochore theory, proposed nearly three decades ago, depicts the mammalian genome as a mosaic of long, fairly homogeneous genomic regions that are characterized by their guanine and cytosine (GC) content. The human genome, for instance, was claimed to consist of five distinct isochore families: L1, L2, H1, H2, and H3, with GC contents of <37%, 37%-42%, 42%-47%, 47%-52%, and >52%, respectivel...

Moles per cent guanine plus cytosine content of 16 lactobacilli provided three taxonomic groups: I, 32.4 to 38.3% with five species; II, 42.7 to 48.0% with six species; III, 49.0 to 51.9% with five species.

in the present study, the interactions of three different lithium species li+, li3+ and ch3li with several different sites of the most stable tautomers of dna nucleo-bases are presented. this investigation is based on the results of thermochemical properties, quantum theory of atoms in molecules (qtaim) and natural bond orbital (nbo) analysis, obtained at b3lyp/6-311++g(d,p) level of theory. th...

background: the phylogenetic location of chinese spirometra sparganum isolates remains unclear. the aim of this study was to explore the phylogenetic location of the spirometra sparganum isolates from china. methods: the 28s ribosomal dna (rdna) d1 sequences of 14 spirometra sparganum isolates collected from thirteen locations in china were analyzed by using neighbor-joining (nj), maximum parsi...

The base-pairing interactions of promutagenic 06-methylguanine (06-MeGua) with cytosine and thymine in deuterated chloroform were investigated by 1H NMR spectroscopy. Nucleosides were derivatized at hydroxyl positions with triisopropylsilyl groups to obtain solubility in nonaqueous solvents and to prevent the ribose hydroxyls from forming hydrogen bonds. We were able to observe hydrogen-bonding...

Rootstocks are well known to have important effects on scion growth performance. However, the involved mechanisms remain unclear. Recent studies provided some clues potential involvement of DNA methylation in grafting, which open up new horizons for exploring how rootstocks induce changes. To better understand rootstock-induced alterations, whole-genome bisulfite sequencing (WGBS) was used eval...

A quantitative theory of directional mutation pressure proposed in 1962 explained the wide variation of DNA base composition observed among different bacteria and its small heterogeneity within individual bacterial species. The theory was based on the assumption that the effect of mutation on a genome is not random but has a directionality toward higher or lower guanine-plus-cytosine content of...

Kennedy's disease, also known as bulbospinal muscular atrophy, is a rare, X-linked recessive neurodegenerative disorder affecting adult males. It is caused by expansion of an unstable cytosine-adenine-guanine tandem-repeat in exon 1 of the androgen-receptor gene on chromosome Xq11-12, and is characterized by spinal motor neuron progressive degeneration. Endocrinologically, these patients often ...