It has been almost 4 decades since the "war on cancer" was declared. It is now generally believed that personalized medicine is the future for cancer patient management. Possessing unprecedented potential for early detection, accurate diagnosis, and personalized treatment of cancer, nanoparticles have been extensively studied over the last decade. In this review, we will summarize the current s...

In this brief review, gold nanoparticles conjugated with functional polymers are described from the viewpoint of application to sensing materials. The optical properties of gold nanoparticles, the synthesis of polymer-functionalized gold nanoparticles, and their analytical applications are discussed. Polymer-functionalized gold nanoparticles are categorized into two classes: biopolymer-conjugat...

We have developed novel gold-silver alloy nanoshells as magnetic resonance imaging (MRI) dual T1 (positive) and T2 (negative) contrast agents as an alternative to typical gadolinium (Gd)-based contrast agents. Specifically, we have doped iron oxide nanoparticles with Gd ions and sequestered the ions within the core by coating the nanoparticles with an alloy of gold and silver. Thus, these nanop...

Introduction: Photothermal therapy using gold nanoshells is one of cancer therapy methods. Gold nanoshells generally consist of a silica core and a thin gold shell. Fe3O4@Au core-shell can be used for magnetic targeted therapy. The objective of this study was investigation of the photothermal effects of magnetically targeted Fe3O4@Au NPs and NIR laser irradiation on model of me...

introduction proton therapy is used to treat malignant tumors such as melanoma inside the eye. proton particles are adjusted according to various parameters such as tumor size and position and patient’s distance from the proton source. the purpose of this study was to assess absorbed doses in eyes and various tumors found in the area of sclera and choroid and the adjacent tissues in radiotherap...

today, use of nanotechnology for cancer therapy is an active field of research. early detection, accurate diagnosis, and individual treatment are the aims which cause nanotechnology as an attractive area for research. among metallic nanomaterials, gold nanostructures have unique properties which make them remarkable candidates for biomedical approaches. surface plasmonic resonance (spr) effect ...

Cell-based therapy offers a promising solution for the treatment of diseases and injuries that conventional medicines and therapies cannot cure effectively, and thus comprises an encouraging arena for future medical breakthroughs. The development of an accurate and quantitative noninvasive cell tracking technique is a highly challenging task that could help in evaluating the effectiveness of tr...

Background: Radiation-sensitive polymer gels are among the most promising three-dimensional dose verification tools and tissue-like developed to date. Among the special features of this type of dosimeters, is be doped with other elements or chemicals which made them appropriate for investigating of dose enhancement with contrast agents, by high atomic number. Material and Methods: In this study...

Introduction: The proton beam produced in particle accelerators has an appropriate therapeutic potential. In this research, proton therapy of breast cancer is simulated using the MCNPX code in a MIRD phantom, also the contribution of scattered neutron dose during the proton therapy were calculated for the Heart, Lung and Liver.   Materials and Methods: For si...