The aim of the experiments was to evaluate the influence of human kisspeptin on LH secretion of Prussian carp (Carassius gibelio) females during ovarian recrudescence and spawning season. For the experiments, human kisspeptin KISS1 (0.1 mg kg(-1) of body weight--b.w.), GnRH analogue (Des Gly(10), D-Ala(6)) GnRH-A (20 µg kg(-1) b.w.) and dopamine antagonist (pimozide) (5 mg kg(-1) b.w.) were use...

The mucosa of the nasal cavity has relatively high premeability for peptides. Because of the digestive peptidase activity of the gut, the nasal pathway is currently the route of choice for nonparenteral administration of many peptides including gonadotropin releasing hormone analogues (GnRH-a) . Nevertheless, the transmucosal route of administration may have some problems. Variations exist from...

overall, 531 dairy cows were inseminated with the aim to study their reproductive performance following administration of gnrh analogue on different days of estrous cycle with different doses. these cows were divided into six treatment and one control group. depending upon different treatment groups, buserelin acetate was injected at a dose of 10.5 µg or 21.0 µg on different days (0, 5 or 12) o...

Protection of testicular integrity against damage from cyclophosphamide (C'Y) by simultaneous treatment with a gonadotropin-releasing hormone (GnRH) analogue was reported in BALB/c mice (L. M. Glode et al., Lancet, 1:1132-1134,1981). This approach has been used as the basis for clinical trials in various treatment centers (D. H. Johnson et al., Blood, 65:832-836,1985) in an attempt to prevent i...

Protection of testicular integrity against damage from cyclophosphamide (CY) by simultaneous treatment with a gonadotropin-releasing hormone (GnRH) analogue was reported in BALB/c mice (L.M. Glode et al., Lancet, 1: 1132-1134, 1981). This approach has been used as the basis for clinical trials in various treatment centers (D. H. Johnson et al., Blood, 65:832-836, 1985) in an attempt to prevent ...

BACKGROUND Despite the clinical outcomes of ovarian stimulation with either GnRH-agonist or GnRH-antagonist analogues for in vitro fertilization (IVF) being well analysed, the effect of analogues on oocyte/embryo quality and embryo development is still not known in detail. The aim of this case-control study was to compare the efficacy of a multiple-dose GnRH antagonist protocol with that of the...