نتایج جستجو برای: glycosylated protein

تعداد نتایج: 1244008  

Journal: :iranian journal of immunology 0
soheila rahgozar division of cell, molecular and developmental biology, department of biology, faculty of science, university of isfahan, isfahan, iran

beta 2 glycoprotein i (β2gpi) is a single chain 50 kda highly glycosylated glycoprotein at an approximate concentration of 4 μm in cells. the abundance of this protein in plasma and its high state of preservation indicate the important role of this protein in mammalian. in addition, β2gpi has a particular structure in the fifth domain, and is categorized as the major antigen recognized by autoa...

Journal: :American journal of physiology. Cell physiology 2004
Teresa M Buck Joel Eledge William R Skach

Aquaporin-2 (AQP2) is the vasopressin-sensitive water channel that regulates water reabsorption in the distal nephron collecting duct. Inherited AQP2 mutations that disrupt folding lead to nephrogenic diabetes insipidus (NDI) by targeting newly synthesized protein for degradation in the endoplasmic reticulum (ER). During synthesis, a subset of wild-type (WT) AQP2 is covalently modified by N-lin...

Journal: :Journal of Immunology 2023

Abstract The pandemic of Coronavirus Disease 2019 (COVID-19) is caused by Severe Acute Respiratory Syndrome 2 (SARS-CoV-2). viral fusion protein, spike binds to its receptor Angiotensin-Converting Enzyme (ACE2) enter host cells. Further, the S1 subunit protein may be cleaved off virus and affect various organs. In addition tightly binding ACE2, also enhances peptidase activity ACE2 activate cel...

Journal: :Bioorganic & medicinal chemistry 2000
B G Davis R C Lloyd J B Jones

Glycoproteins occur naturally as complex mixtures of differently glycosylated forms which are difficult to separate. To explore their individual properties, there is a need for homogeneous sources of carbohydrate-protein conjugates and this has recently prompted us to develop a novel method for the site-selective glycosylation of proteins. The potential of the method was illustrated by site-sel...

Journal: :Diseases of aquatic organisms 2001
S Griffiths M Cook B Mallory R Ritchie

The characterisation of 2 infectious salmon anemia virus (ISAV) proteins is described. Proteins were harvested from ISAV-infected Chinook salmon embryo (CHSE)-214 cell culture by continuous elution denaturing gel electrophoresis, enabling the harvest of specific molecular weight fractions. Through the use of a polyclonal antiserum to ISAV, it was possible to identify a potentially autolytic maj...

Journal: :Diabetes 1980
A L Kennedy T D Mehl T J Merimee

The presence of free glucose in serum was found to interfere with accurate measurement, by a colorimetric method, of nonenzymatically glycosylated serum proteins. A mean elevation to 241% of basal levels was observed in the serum of 11 nondiabetic subjects to which glucose, in a concentration of 300 mg/dl, had been added immediately before assay. After dialysis of serum samples to remove glucos...

اصغری نکاح, سید محسن, بهنام وشانی, حمیدرضا, حسینی, سید جواد, فیروز, محبوبه, مظلوم, سیدرضا,

Background and purpose: Adolescents with diabetes are faced with some constraints and may show some negative reactions such as aggressive behavior. These behaviors increase the level of glycosylated hemoglobin in these patients. It is important to assess some interventions that reduce aggression and improve glycosylated hemoglobin level in diabetic adolescents. This study aimed at determining t...

2011
Jason E. Hudak Helen H. Yu Carolyn R. Bertozzi

Homogeneously glycosylated proteins are important targets for fundamental research and for biopharmaceutical development. The use of unnatural protein-glycan linkages bearing structural similarity to their native counterparts can accelerate the synthesis of glycoengineered proteins. Here we report an approach toward generating homogeneously glycosylated proteins that involves chemical attachmen...

Journal: :The Journal of biological chemistry 2013
Marina Shenkman Bella Groisman Efrat Ron Edward Avezov Linda M Hendershot Gerardo Z Lederkremer

Studies of misfolded protein targeting to endoplasmic reticulum-associated degradation (ERAD) have largely focused on glycoproteins, which include the bulk of the secretory proteins. Mechanisms of targeting of nonglycosylated proteins are less clear. Here, we studied three nonglycosylated proteins and analyzed their use of known glycoprotein quality control and ERAD components. Similar to an es...

2016
Abdul A. Waheed Scott MacDonald Maisha Khan Megan Mounts Maya Swiderski Yue Xu Yihong Ye Eric O. Freed

The HIV-1 accessory protein Vpu enhances virus release by counteracting the host restriction factor tetherin. To further understand the role of host cell proteins in Vpu function, we carried out yeast two-hybrid screening and identified a previously reported Vpu-interacting host factor, small glutamine-rich tetratricopeptide repeat-containing protein (SGTA). While RNAi-mediated depletion of SGT...

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