Neural stem cells (NSCs) were recently revealed to exist in the hypothalamus of adult mice. Here, following our observation showing that a partial loss of hypothalamic NSCs caused weight gain and glucose intolerance, we studied if NSCs-based cell therapy could be developed to control these disorders. While hypothalamus-implanted NSCs failed to survive in mice with obesity, NF-κB inhibition indu...

OBJECTIVE To compare the development of diabetes mellitus in subjects with and without the sign of the Cross of Andreas in the iris over a period of four years. METHOD A prospective, descriptive study of quantitative approach. This cohort study had 91 patients without the disease, with and without the signal. The monitoring was conducted by means of the records in medical charts. RESULTS At...

BACKGROUND Insulin resistance (IR) contributes to the development of glucose intolerance (post-transplant diabetes mellitus or impaired glucose tolerance) following renal transplantation. Furthermore, endothelial dysfunction (ED) is associated with IR. Glucose intolerance, IR and ED are all independent risk factors for cardiovascular disease. Therefore, treatment with insulin sensitizers may be...

CONTEXT The prevalence of type 2 diabetes is increasing in the Bangladeshi population. However, there is little information available on the prevalence of glucose intolerance, ie, type 2 diabetes, impaired glucose tolerance, and impaired fasting glucose. AIMS The main aim of this study is to determine the prevalence of different categories of glucose intolerance and their relationship with di...

Objective: The objective of the present study was to examine the association of glucose intolerance and type-2 diabetes mellitus with the -174 G > C and -308 G > A allelic variations of IL-6 and TNF-α, respectively, through anthropometric measurements and age strata. Methods: This is a cross-sectional study using data from 285 community dwelling elderly women who underwent physical, biochemical...

The recognition of three cases of lactose intolerance in the Sheffield Children's Hospital led to an investigation into the specific determination of plasma and urinary lactose levels following lactose loading tests. Using the method of Reithel (1962) (see below) it was found that aqueous solutions of lactose (0.1 ml.) were readily and consistently determined even at levels down to 5 mg. per 10...

In a study of prevention of spontaneous diabetes in BB rats by therapeutic doses of cyclosporine (10 mg/kg/day), the male control non-diabetes-prone rats showed glucose intolerance after a 0.25 g/kg glucose load by gavage, at 90 and 130 days of treatment. Non-BB male Wistar rats treated similarly showed glucose intolerance at 1 wk of treatment, with progressive worsening for 5 wk, then sustaine...