Background: Phosphodiesterases (PDEs) play a major role in the regulation of cyclic adenosine monophosphate (cAMP)- and cyclic guanosine monophosphate (cGMP)-mediated pathways. Their inhibitors exhibit anti-inflammatory, vasodilatory and antithrombotic effects. Therefore, consumption of foods with PDE-inhibiting potential may possess beneficial influence on the risk of cardiovascular diseases. ...

background: the spice zingiber officinale or ginger possesses antioxidant activity and neuroprotective effects. in this study we hypothesized that treatment with hydroethanolic extract of ginger (50, 100 and 200 mg/kg, p.o) would effect on the hyoscine-induced memory impairment in rats. methods: in this experimental study 64 male wistar rats were divided into eight groups (8 rats in each group)...

INTRODUCTION Ginger has a long history of medicinal use, particularly as an anti-inflammatory agent for a wide variety of diseases such as arthritis. Suppression of inflammation in arthritis is attributed to suppression of proinflammatory cytokines and chemokines produced by synoviocytes, chondrocytes, and leukocytes. OBJECTIVE This study aimed to elucidate the effect of a combination ginger ...

OBJECTIVE Association between chronic alcohol intake and cardiac abnormality is well known; however, the precise underlying molecular mediators involved in ethanol-induced heart abnormalities remain elusive. This study investigated the effect of chronic ethanol exposure on calcium/calmodulin-dependent protein kinase IIδ (CaMKIIδ) gene expression and monoamine oxidase (MAO) levels and histologic...

The use of botanical medicine is ancient, and plant chemicals are still the backbone of our pharmacopoeia because more than 50 % of drugs used in Western pharmacopoeia are isolated from herbs or derived from modification of chemicals first found in plants. Zingiber officinale Roscoe. (Ginger) is a spice that has been used from two thousand years ago as a medicine in several Asian countries. Rec...

BACKGROUND Ginger is one of the most important spice crops and traditionally has been used as medicinal plant in Bangladesh. The present work is aimed to find out antioxidant and anticancer activities of two Bangladeshi ginger varieties (Fulbaria and Syedpuri) at young age grown under ambient (400 μmol/mol) and elevated (800 μmol/mol) CO2 concentrations against two human breast cancer cell line...

The extract of ginger (Zingiber officinale Roscoe) and its major pungent components, [6]-shogaol and [6]-gingerol, have been shown to have an anti-proliferative effect on several tumor cell lines. However, the anticancer activity of the ginger extract in pancreatic cancer is poorly understood. Here, we demonstrate that the ethanol-extracted materials of ginger suppressed cell cycle progression ...