stats are a family of latent transcription factors that reside in the cytoplasm of resting cells. the stat1 transcription factor gene located on the chromosome 2 at interval 60 to 63 cm. this factor upon stimulation with inf gamma, dimerizes and translocate to the nucleus where mediates transcriptional regulation. in this study, we estimated the allele and genotype frequencies of stat1/pag1 gen...

background: vascular calcification is an important stage in atherosclerosis. during this stage, vascular smooth muscle cells (vsmc) synthesize many osteogenic factors such as osteonectin (encoded by sparc). oxidative stress plays a critical role in atherosclerosis progression, and its accumulation in the vascular wall stimulates the development of atherosclerosis and vascular calcification. the...

Abstract In eukaryotes three major nuclear RNA Polymerases (Pols I, II and III) transcribe the genome. Pols III many different genes. Pol I has only one target from which it synthesizes precursor for 3 of 4 ribosomal (r)RNAs accounting up to 60 percent total cellular RNA. Dedication its specific transcription factors a single gene underlines importance rRNA synthesis. Research in Regensburg aim...

The full-length coat protein gene of Grapevine fanleaf virus (GFLV) isolates from Iran was characterized byreverse transcription polymerase chain reaction (RTPCR) and sequencing. The expected 1515 bp coatprotein (CP) gene amplicon was obtained for 16 isolates out of 89 that were identified by double antibodysandwich enzyme-linked immunesorbent assay (DASELISA) in a population ...

Infertility as a vital process in human reproduction involves many couples worldwide. Although many genetic causes of infertility are known, the genetic basis of infertility in men is largely unknown. Therefore, the identification of genetic biomarkers in this field is important and genetic polymorphisms in key genes of the spermatogenesis pathway can be valuable biomarkers in this field. Gene'...

When cells enter mitosis, they undergo series of dramatic changes in their structure and function that severely hamper gene regulatory processes transcription. This raises the question how daughter efficiently recapitulate expression profile mother such cell identity can be preserved. Here, we review recent evidence supporting view distinct chromatin-associated mechanisms gene-regulatory inheri...

The WRKY gene family encodes a large group of transcription factors that regulate genes involved in plant response to biotic and abiotic stresses. Sorghum is a notable grain and forage crop in semi-arid regions because of its unusual tolerance against hot and dry environments. We identified a set of 85 WRKY genes in the S. bicolor genome and classified them into three groups (I–III). Among the ...

Abstract Gene expression (GE) is an inherently random or stochastic noisy process. The randomness in different steps of GE, e.g., transcription, translation, degradation, etc., leading to cell-to-cell variations mRNA and protein levels. This variation appears organisms ranging from microbes metazoans. Stochastic GE has important consequences for cellular function. fluctuations levels produce va...

Abstract The periodic transcription output is ubiquitously observed in an isogenic cell population. To understand mechanisms of cyclic behavior transcription, we extend the gene activation process two-state model by assuming that synthesis rate periodic. We derive analytical forms mean transcript level and noise. limits them indicate noise display behaviors. Numerical examples strongly suggest ...