BACKGROUND Antimicrobial susceptibility of Legionella spp. has rarely been studied in Korea. Therefore, we aimed to determine the susceptibility of Legionella spp. to various antibiotics. METHODS We assessed the antimicrobial susceptibility of 66 environmental and clinical Legionella isolates collected between January 2001 and December 2008 from Korea and Japan. The minimum inhibitory concent...

OBJECTIVES Mycoplasma genitalium and Chlamydia trachomatis are the primary pathogens detected from non-gonococcal urethritis (NGU). In this study, the efficacy of gatifloxacin was examined against M genitalium-related urethritis. METHODS The study was an open clinical trial evaluating the effectiveness of gatifloxacin with 200 mg doses twice a day for 7 days against male NGU. RESULTS Betwee...

The use of fluoroquinolones for the treatment of community-acquired respiratory tract infection is increasing. Since for Streptococcus pneumoniae a ratio of the 24-h area under the concentration-time curve (AUC(24)) for the agent to the MIC (AUC(24)/MIC) greater than 30 for the fraction of unbound drug (f(u)) is the major pharmacokinetic-pharmacodynamic (PK-PD) parameter correlating with bacter...

Gatifloxacin is a recently marketed quinolone with an enhanced activity against gram-positive bacteria compared with that of ciprofloxacin (4, 12, 13, 18). The structural differences between gatifloxacin and ciprofloxacin are substituents at the C-8 position of the quinolone nucleus (gatifloxacin, C-8-methoxy; ciprofloxacin, C-8-H) and at the C-3 position of the piperazinyl moiety of the C-7 po...

UNLABELLED Objective : To assess the efficacy of Gatifloxacin 0.3% ophthalmic solution in infective corneal ulcer. Methods : This observational (non comparative) clinical analysis was done at the Department of ophthalmology unit-II, Liaquat University Eye hospital Hyderabad of Liaquat University of Medical and Health Sciences Jamshoro / Sindh, Pakistan from April 2010 to March 2012. All the sub...

Objectives: The objective of this study was to evaluate and compare the effectiveness gatifloxacin ceftriaxone as prophylactic antibiotic in elective clean surgical procedures. Methods: Sixty patients, undergoing laparoscopic cholecystectomy, were recruited consecutively divided into two groups, that is, Group A B 30 patients each. In A, a pre-operative dose injection 1 g administered intraveno...

BACKGROUND Gatifloxacin has been associated with both hypoglycemia and hyperglycemia. We examined dysglycemia-related health outcomes associated with various antibiotics in a population of approximately 1.4 million Ontario, Canada, residents 66 years of age or older. METHODS We conducted two population-based, nested case-control studies. In the first, case patients were persons treated in the...

PURPOSE The aim of this study was to evaluate the safety and efficacy of topical besifloxacin ophthalmic suspension 0.6% compared with gatifloxacin ophthalmic solution 0.3% in the treatment of bacterial conjunctivitis in neonates. METHODS This was a multicenter, randomized, double-masked, parallel group study. Subjects ≤31 days of age with severity grade ≥1 (scale 0-3) for both conjunctival d...

BACKGROUND Seventeen 1,4-dihydroquinoline-3-carboxamide and 1,4-dihydroquinoline-3-carbohydrazide derivatives of gatifloxacin have been prepared with a facile one step synthesis aiming to improve antibacterial, antifungal and immunological activities. The methodology allows the introduction of a variety of substituents such as amines, alcohol, phenol, amides and alkyl halides into the core stru...

Pancreatic cancer, despite being the most dreadful among gastrointestinal cancers, is poorly diagnosed, and further, the situation has been aggravated owing to acquired drug resistance against the single known drug therapy. While previous studies have highlighted the growth inhibitory effects of older generation fluoroquinolones, the current study aims to evaluate the growth inhibitory effects ...