Background Keratoconus (KCN) is a bilateral, progressive, and non-inflammatory disorder in the cornea, which results thinning protrusion of cornea. Objective This study aims to determine effectiveness using pachymetric progression indices (PPIs) grading severity KCN disease. Methods In this study, 76 patients with different stages were enrolled. The was graded according maximum keratometry, cor...

The effect of ouabain on the hydration of the rabbit cornea has been studied. The glycoside was found to prevent the dehydration of the cornea during temperature reversal procedures and its application to the cornea in vivo results in significant corneal swelling. A comparison of the effect of ouabain on the cornea to the drug's effect on electrolyte transport systems in the tissues suggests th...

introduction: the cell surface glycoconjugate and extracellular matrix may mediate extracellular signals which decide the fate of the cells during tissue interactions. the proper development of cornea needs cellular interaction between surface epithelium, neural crest and developing lens. materials and methods: 50 pregnant rats were chosen and the embryos from pernatal day11-to 20 and postnatal...

1. Abstract Corneal refractive surgery is a promising technique to correct irregularities of cornea shape accompanying various types of aberration in eye ball system, and correction of refractive power for nearsightedness and farsightedness are fundamental application of refractive surgery. However there have been reported some risks such as over-/under-corrections, abnormal sight symptom like ...

AIMS For the study of transcorneal in vitro permeation of ophthalmic drugs, excised animal cornea or corneal epithelial cell culture are frequently used as a replacement for the human cornea. The main purposes of this study were to reconstruct a complete human organotypic cornea equivalent, consisting of all three different cell types (epithelial, stromal, and endothelial); to test the barrier ...

Aims: For the study of transcorneal in vitro permeation of ophthalmic drugs, excised animal cornea or corneal epithelial cell culture are frequently used as a replacement for the human cornea. The main purposes of this study were to reconstruct a complete human organotypic cornea equivalent, consisting of all three different cell types (epithelial, stromal, and endothelial); to test the barrier...

Keratoconus (KC) is a bilateral sight threatening disease that affects the cornea. It consists of gradual steepening central cornea associated with irregular astigmatism and may lead to corneal opacities. In some cases, keratoplasty needed restore vision. Even though it not frequent, recurrence KC in donor tissue has been described, usually bilateral. Recurrence respond problems related graft o...

Macromolecules from normal rabbit cornea and cornea containing a 2-mm diameter button of scar tissue were biosynthetically labeled with 35S-sulfate and 3H-glucosamine in vivo and in organ culture. Labeled macromolecules, including proteoglycans (PGs) extracted from the normal cornea, scar tissue, and corneal tissue adjacent to the scar with guanidine hydrochloride were chromatographed on DEAE-S...