We demonstrate using conditional mutagenesis that Pbx1, with and without Pbx2(+/-) sensitization, regulates regional identity and laminar patterning of the developing mouse neocortex in cortical progenitors (Emx1-Cre) and in newly generated neurons (Nex1-Cre). Pbx1/2 mutants have three salient molecular phenotypes of cortical regional and laminar organization: hypoplasia of the frontal cortex, ...

Neuroinflammation seems to be involved in the pathophysiology of Huntington’s Disease (HD), but its specific role on different stages disease, especially later stages, remains understood. Here in, we investigated concentrations cytokines, chemokines and neurotrophic factors striatum frontal cortex 24-month-old BACHD mice, a murine model that displays several behavioral pathological features hum...

To investigate the functional neuroanatomy associated with retrieving semantic and episodic memories, we measured changes in regional cerebral blood flow (rCBF) with positron emission tomography (PET) while subjects generated single word responses to achromatic line drawings of objects. During separate scans, subjects either named each object, retrieved a commonly associated color of each objec...

Recent anatomical findings in the monkey indicate that the frontal cortex receives associative afferents from the visual, auditory, and somatosemsory areas of the cortex. The inferior parietal lobule and the inferior temporal cortex are important way-stations in these cortico-cortical afferent pathways. The olfactory system represents a fourth sensorium having access to the frontal cortex, name...

We performed meta-analyses on 60 neuroimaging (PET and fMRI) studies of working memory (WM), considering three types of storage material (spatial, verbal, and object), three types of executive function (continuous updating of WM, memory for temporal order, and manipulation of information in WM), and interactions between material and executive function. Analyses of material type showed the expec...