Drug induced liver injury is a recognised cause of acute liver failure. A wide range of drugs have been implicated, of which the most common are Paracetamol and antibiotics. Nitrofurantoin is a commonly prescribed antimicrobial which may cause liver injury from either acute or chronic exposure. This complication was thought to occur with an extremely low incidence; however recent data suggests ...

1Office of Computational Science, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, MD, USA 2Center of Pharmacology and Toxicology, Hannover Medical School, Hannover, Germany 3Department of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR, USA 4Division of Bioinformatics and Biostatistics, National Center for Toxicological Research,...

Drug-induced liver injury (DILI) is an important cause of mortality and morbidity in the general population. Patients suffering from DILI may present with symptoms ranging from minor, nonspecific changes in hepatic structure and function to fulminant hepatic failure or chronic hepatitis. Thiocolchicoside is widely used as a muscle relaxant. The primary side effects of thiocolchicoside are nause...

Drug-induced liver injury is a frequent cause of hepatic dysfunction. Reliably establishing whether the liver disease was caused by a drug requires the exclusion of other plausible causes and the search for a clinical drug signature. The drug signature consists of the pattern of liver test abnormality, the duration of latency to symptomatic presentation, the presence or absence of immune-mediat...

Drug-induced liver injury (DILI) is common and nearly all classes of medications can cause liver disease. Most cases of DILI are benign, and improve after drug withdrawal. It is important to recognize and remove the offending agent as quickly as possible to prevent the progression to chronic liver disease and/or acute liver failure. There are no definite risk factors for DILI, but pre-existing ...

Drug-induced liver injury (DILI) remains the most common cause of acute liver failure (ALF) in the western world. Excluding paracetamol overdose, nearly all DILI encountered in the clinical setting is idiosyncratic in nature because affected individuals represent only a small proportion of those treated with such drugs. In many cases, the mechanism for idiosyncrasy is immune-mediation and is of...

Hepatoprotective effect of gallic acid against type 2-induced diabetic liver injury in male rats through modulation fetuin-A and GLP-1 with involvement ERK1/2/NF-κB Wnt1/β-catenin signaling pathways