objective: rosa damascena mill l (r. damascena) is a medicinal plant mostly known in the world for its perfume. it also has beneficial effects on stress, tension and depression. in this experiment antidepressant effect of ethanolic extract of r. damascena by forced swimming test (fst) was evaluated. material and methods: animals received ethanolic extract (15, 60 and 90 mg/kg, i.p), imipramine ...

methanol extract of dried leaves of momordica charantia linn ( cucurbitaceae ) was investigated for anxiolytic, antidepressant and anti-inflammatory activities in animal models. anxiolytic activity of methanol extract of dried leaves of momordica charantia linn was tested by elevated plus maze test and the results showed a significant anxiolytic effect comparable, with diazepam in all the teste...

The effects of melatonin administered chronically on forced-swim test and open-field test behaviours were examined in male and female rats. The forced-swim test has been shown to be sensitive to all major classes of antidepressants and evidence indicates that melatonin possesses putative antidepressive properties. Male and female Long-Evans rats received either a regimen of chronic administrati...

In the present study, we examined the effects of imipramine (IMI) and metyrapone (MET) given alone or in combination of IMI and MET in the forced swimming test in rats. We also measured pharmacokinetic parameters: the level of IMI and its metabolite, desipramine (DMI), in the rat plasma and brain (1 h after the forced swimming test). The present studies indicate that MET (50 mg/kg) reduced immo...

Hyperactivity of the hypothalamic pituitary-adrenal (HPA) axis plays a role in the pathophysiology of major depressive disorder (MDD). Recent studies suggest the role of the glutamatergic system in the pathophysiology of MDD, and N-methyl-D-aspartate (NMDA) receptor antagonists have shown antidepressant effects in both preclinical and clinical studies. However, little is known about the role of...

The aim of the present study was to examine the effect of combined treatment of male Wistar rats with pramipexole and fluoxetine or sertraline in the forced swimming test. The obtained results showed that co-treatment with pramipexole (0.1 mg/kg) and fluoxetine (10 mg/kg) or sertraline (5 mg/kg) (in doses inactive per se) exhibited antidepressant-like activity in the forced swimming test. Sulpi...

OBJECTIVE To assess developmental capacity of fertilised oocytes by sperm of mouse exposed to forced swimming stress. METHODS The experimental study was conducted at the Physiology Research Center of Ahvaz Jundishapur University of Medical Sciences, from August 2011 to January 2012. It comprised 20 adult male and 10 female mice. The male mice were randomly divided into two equal groups (n=10)...

AIM The aim of the study was to compare the effects of conventional exercise (CE), swimming and walking on the pulmonary functions, aerobic capacity, quality of life, Bath indexes and psychological symptoms in patients with ankylosing spondylitis (AS). METHODS Forty-five patients were randomised into either swimming (group 1), walking (group 2), CE group (group 3). Patients in Group 1 perform...