Paramagnetic metals are frequently used to regulate fluorescence emissions in chemical and biological probes. Accurate quantum calculations offer the first regulation theory that quenching is through the competitive nonradiative decay of the mixed fluorophore/metal (3)ππ*/dd state isoenergetic to the fluorophore-localized (1)ππ* state.

Abstract Fluorophore 1,8-naphthilamide was linked to 2-bromoacridine through an ethylenediamine spacer using a succinct synthetic route give bromoacridine-linked, bifunctional fluorophore conjugate for the detection of triplex DNA. Acridine is well known intercalate into duplex DNA whereas introduction bulky bromine atom at position C2 redirects specificity over In this work, photoelectron tran...

We report the synthesis of a series fluorophore and alkyne-derived 5,17-difunctionalised calix[4]arenes their application in detection Au 3+ .

Small molecules can display certain electronic and structural features that enable their use for metal-sensing applications in different fields. Of the reported metal sensors, there has been increasing interest copper sensing past decade, given biological importance of as well its presence a potential contaminant water fuels. Molecules used copper(II) generally consist fluorophore/chromophore l...

A fluorophore labeled oligonucleotide could induce aggregation of a positively charged perylene probe. The perylene aggregate could very efficiently quench the fluorescence of the labeled fluorophore. Based on this observation, a new method for the highly sensitive and selective detection of a protein has been developed.

In fluorophore-cored dendrimers with peripheral binding functionalities, the effect of generation upon protein binding-induced fluorescence quenching can be unpredictable; this is because the increase in fluorophore-binding functionality distance with generation is also accompanied by an increase in the number of binding moieties and the interplay between the two features is utilized to create ...

Using fluorophore specific to zinc, a well-established prostate cancer marker, to detect prostate cancer will be challenged by the “reverse-uptake” of the fluorophore. A sensitivityadapted reconstruction method may improve the target recovery in axial-imaging geometry. ©2010 Optical Society of America OCIS codes: (170.7230) Urology; (170.6960) Tomography; (170.3010) Image reconstruction techniq...

Convenient and efficient synthesis of a new environmentally sensitive chlorine-substituted 2,3-naphthalimide-based fluorophore is reported. Benzotriazole carboxyl group activation of the 6-chloro-fluorophore enabled quick labeling of free and Fmoc-protected amino acids. The photophysical properties of the compounds obtained include high quantum yields in solvents of different polarity: water, m...

A FRET assembly reports antibiotic affinities to two different RNA targets. A binder was labeled with a fluorophore that acts both as an acceptor for the emissive nucleoside on the bacterial A-site and a donor fluorophore for the terminally-labeled human A-site. Unlabeled drugs were used to dissociate the labeled antibiotic.