Polymethylated Flavonols, Identification, Enzymatic Synthesis, O-Methyltransferase, Chrysosplenium americanum, Saxifragaceae The major flavonoid constituents of Chrysosplenium americanum (Saxifragaceae) were identi­ fied by UV-, NMRand mass spectroscopy and the analysis of their hydrolytic products. They consisted of two 2'-0-/?-D-glucosides of partially methylated 2'-hydroxyquercetin and four ...

Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Receptors (TRAIL-R) are an important factor of apoptosis in cancer cells. There are no data about the effect of flavonols on the receptor expression on a surface of macrophage like cells. In this study, the expression level of TRAIL-R1 on murine RAW264.7 macrophages in the presence of selected flavonols: galangin, kaempferol, kaempferide a...

Astragalus membranaceus (Fisch.) Bunge has been was successfully acclimated in Central Europe. We report the content of isoflavones and some other polyphenolic compounds in roots and aerial parts that have been analyzed by means of TLC and HPLC. The total amount of isoflavones in leaves, was 0.55 mg g(-1) dry weight, and of the flavonols--up to 3.54 mg g(-1). In the roots isoflavonoid content w...

The signaling pathways regulated by mitochondria involve among others, the intrinsic apoptotic pathway, calcium homeostasis and reactive oxygen species signaling, ATP synthesis. aim of this review is to narrate importance flavanoids (e.g., flavones, flavonols, flavonols-3-ols, anthocyanidins isoflavones) in mitochondrial biogenesis. Therefore, induction biogenesis can be stimulated nutrition st...

OBJECTIVE Flavonoids, as antioxidants, may prevent the progressive impairment of pancreatic beta-cell function due to oxidative stress and may thus reduce the occurrence of type 2 diabetes. The aim of the present study was to examine the association of dietary flavonol and flavone intake with type 2 diabetes, and biomarkers of insulin resistance and systemic inflammation. METHODS In 38,018 wo...

Tw o different O -glucosyl transferases (F 3 G T and F 7 G T ) catalyzing the transfer o f D-glucose from U D P-D -glucose to the 3 and 7 positions o f flavonol, respectively, were isolated from the young leaves o f Paederia scandens var. mairei. F 3 G T and F 7 GT, which were recov­ ered in about a 1:1 ratio in the activity, were purified by about 140and 136-fold, respectively, by precipitatio...

BACKGROUND Calibrachoa x hybrida (Solanaceae) cultivars are widely used in North and South America as ornamental plants. Their potential as a source of antimicrobial compounds might be enhanced by seaweed extract (SWE) applications. METHODS SWE of Ascophyllum nodosum were applied at 5 and 7 ml/L as a soil drench or foliar spray on Calibrachoa cultivars of Superbells® 'Dreamsicle' (CHSD) and S...