Abstract There has been an increase in the identification of cases coal workers’ pneumoconiosis (CWP) recent years around world. While there are a range possible explanations for this, studies have implicated pyrite content as key determinant CWP risk. However, experimental to support this link limited. The aim study was assess association between content, and subsequent release bioavailable ir...

Chronic kidney disease (CKD) is a worldwide health problem affecting 9.1% of the world’s population. The treatments to prevent progression CKD remain limited, however. Resident fibroblasts in kidneys play crucial roles pathological conditions commonly recognized CKD, such as renal fibrosis, anemia, and peritubular capillary loss. Fibroblasts provide structural backbone by producing extracellula...

Extremely low frequency electromagnetic fields (ELF-EMFs) are non-ionizing, low-energy, fields, capable of inducing biological effects such as cell migration, proliferation and differentiation, cytokine growth factors expression, NO signaling alteration. In vitro experiments have shown an interaction ELF-EMFs with all the phases wound healing. This in knowledge could be applied clinical practic...

Background: The regenerative capacity of the mammalian heart is quite limited. Recent reports have focused on reprogramming mesenchymal stem cells into cardiomyocytes. We investigated whether fibroblasts could transdifferentiate into myocardium.Methods: Mouse embryonic fibroblasts were treated with Trichostatin A (TSA) and 5-Aza-2-Deoxycytidine (5-aza-dC). The treated cells were permeabilized w...

Introduction Identification and purification of mesenchymal stem cells (MSCs) expanded in culture for therapeutic use is crucial improved yield optimal results. Fibroblasts are the most common cell type connective tissue commonly found as contaminants MSC cultures, affecting potentially causing tumor formation after transplantation. In current study, we wished to identify surface markers that c...

introduction: the process of wound healing sets in motion a complex and dynamic series of events, which includes the remodeling of the extracellular matrix degradation of matrix proteins, predominantly collagen fibers, mediated by matrix metalloproteinase (mmps). our aim was to demonstrate whether fibroblasts derived from various strains of human fetal foreskin (fs) and adult skin (as), when cu...

Bone marrow-derived mesenchymal stromal cells (MSCs) are major players in regenerative therapies for wound healing via their paracrine activity, mediated partially by exosomes. Our purpose was to test if MSC-derived exosomes could accelerate enhancing the biological properties of main cell types involved key phases this process. Thus, effects on (i) macrophage activation, (ii) angiogenesis, (ii...

Cement is utilized extensively in the manufacturing of concrete, which makes it most common material used building construction. However, usage a great deal cement results CO2 emissions, leads to greenhouse effect. Numerous studies have developed use nano-SiO2 concrete materials lower content mixtures while improving mechanical properties. Additionally, number demonstrated that silica NPs trigg...