Placental transport of vitamin B(12) was studied in the pregnant rat in two series of experiments. In the first series animals were given cyanocobalamin-(57)Co intravenously at various stages of gestation. High specific activity tracer was used and doses of B(12) were 1-2 ng per animal. The rats were killed from 15 min to 24 hr after injection and the fetuses, placentas, and serum were assayed ...

Sexual reproduction in the ocean necessitates only the combination of gametes, followed by absorption of nutrients and oxygen from the surrounding watery medium. As life moved from the sea to the land, reproductive strategies required compensation for the loss of this aquatic environment. For mammals and a few other animals, the solution to this problem was the development of the placenta, the ...

Invasive placenta, often involving placenta accreta, placenta increta, and placenta percreta, is a life-threatening complication of pregnancy characterized by invasion of placental villi into the underlying myometrium. Invasive placenta is usually diagnosed as a result of abnormalities encountered during removal of the placenta at delivery. Because of profuse hemorrhaging in the early postpartu...

Introduction. The coronavirus disease pandemic (COVID-19) is a leading global health and economic concern. danger to the mother fetus during pregnancy from infection with SARS-CoV2 still being studied. New evidence suggests that SARS-CoV-2 causes oxidative stress immune system activation, cytokine storm subsequent tissue damage. Objective. To establish pathogenetic role of in occurrence severit...

Placenta formation occurs through a complex and coordinated effort between the fetus’s extraembryonic tissues and the gravid endometrial tissues. Many macrophages are present in the placenta throughout pregnancy and have been detected as early as day 10 of pregnancy (Chang et al., 1993). Placental macrophages include Hofbauer cells of the fetal chorionic villi and decidual macrophages of the ma...

The placenta is an organ that clinicians and embryologists would all agree is important for pregnancy success. Unfortunately, however, they too often ignore it when they are exploring causes for embryonic, fetal and perinatal complications. The core function of the placenta is to mediate the transport of nutrients between the maternal and fetal circulation, but it also has critical endocrine fu...

Zika virus (ZIKV) crosses the placenta and causes congenital disease. Here we develop an animal model utilizing direct ZIKV inoculation into the uterine wall of pregnant, immunocompetent mice to evaluate transplacental transmission. Intrauterine inoculation at embryonic day (E) 10, but not E14, with African, Asian or American strains of ZIKV reduces fetal viability and increases infection of pl...

Fetal arrythmia is reported to affect 1-2% of pregnancies. Besides digoxin not many drugs have been tried in treating such cases. After confirming 1:1 conduction between atrium and ventricle, no structural heart disease fetus normal echocardiography ECG mother, verapamil was given the treatment fetal supraventricular tachycardia. The drug crossed placenta revert SVT sinus rhythm without harming...

The mammalian fetus is unique in its dependence during gestation on the supply of maternal nutrients through the placenta. Maternal supply and fetal demand for nutrients need to be fine tuned for healthy growth and development of the fetus along its genetic trajectory. An altered balance between supply and demand can lead to deviations from this trajectory with long-term consequences for health...