نتایج جستجو برای: fatty acid elongase gene

تعداد نتایج: 1796572  

2015
John G. Purdy Thomas Shenk Joshua D. Rabinowitz

Human cytomegalovirus (HCMV) infection rewires host cell metabolism, up-regulating flux from glucose into acetyl-CoA to feed fatty acid metabolism, with saturated very long-chain fatty acids (VLFCA) required for production of infectious virion progeny. The human genome encodes seven elongase enzymes (ELOVL) that extend long chain fatty acids into VLCFA. Here we identify ELOVL7 as pivotal for HC...

2010
Eun Ju Kim Min-Kyoung Kim Xing-Ji Jin Jang-Hee Oh Ji Eun Kim Jin Ho Chung

We investigated the alterations of major fatty acid components in epidermis by natural aging and photoaging processes, and by acute ultraviolet (UV) irradiation in human skin. Interestingly, we found that 11,14,17-eicosatrienoic acid (ETA), which is one of the omega-3 polyunsaturated acids, was significantly increased in photoaged human epidermis in vivo and also in the acutely UV-irradiated hu...

پایان نامه :دانشگاه تربیت معلم - تهران - دانشکده علوم پایه 1390

نقش فزاینده رادیکال های آزاد و اکسید کننده های وابسته در فرایند پیری و بیماری زایی آشکار شده است ، نظر به افزایش روز افزون مقدار رادیکال های آزاد در سیستم حیاتی، استفاده از آنتی اکسیدان ها جهت جلوگیری از اثرات مخرب آنها اهمیت می یابد. بررسی تحقیقات انجام شده در زمینه قدرت آنتی اکسیدانی میوه ها و سبزیجات، انار را در گروه میوه های مهم واجد اثرات آنتی اکسیدانی قوی قرار داده است، لذا در این پژوهش ا...

2013
Royah Vaezi Johnathan A. Napier Olga Sayanova

In order to identify novel genes encoding enzymes involved in the biosynthesis of nutritionally important omega-3 long chain polyunsaturated fatty acids, a database search was carried out in the genomes of the unicellular photoautotrophic green alga Ostreococcus RCC809 and cold-water diatom Fragilariopsis cylindrus. The search led to the identification of two putative "front-end" desaturases (Δ...

Journal: :The Journal of pharmacology and experimental therapeutics 2008
Yuji Tanaka Lauren M Aleksunes Ronnie L Yeager Maxwell A Gyamfi Noriko Esterly Grace L Guo Curtis D Klaassen

NF-E2-related factor 2 (Nrf2) is a transcription factor that is activated by oxidative stress and electrophiles that regulates the expression of numerous detoxifying and antioxidant genes. Previous studies have shown that Nrf2 protects the liver from xenobiotic toxicity; however, whether Nrf2 plays a role in lipid homeostasis in liver is not known. Accordingly, wild-type and Nrf2-null mice were...

2012
Yun-tao Li Yuan-min Zhu Chun-hua Fu Mao-teng Li Long-jiang Yu

The genes encoding Δ6 desaturase, Δ6 fatty acid elongase, and Δ5 desaturase from the alga, Phaeodactylum tricornutum, were co-expressed in Arabidopsis thaliana under the control of the Brassica napus napin promoter to produce arachidonic acid (ARA; 20:4 Δ 8, 11, ) and eicosapentaenoic acid (EPA; 20:5 Δ 8, 11, 14, ). ARA and EPA accumulated up to 0.5% and 0.05% of total fatty acids, respectively...

Journal: :The British journal of ophthalmology 2010
Anne McMahon Wojciech Kedzierski

Recent studies have established that retinal health depends on the presence of polyunsaturated C28-C36 fatty acids, in addition to docosahexaenoic acid (DHA, C22:6n-3). Initially characterised 20 years ago, these C28-C36 fatty acids are found as sn-1 acyl components of retinal phosphatidylcholines (PCs), which have DHA in the sn-2 position. This unique PC species is found in both rod- and cone-...

Journal: :Journal of cell science 2011
Liên Bach Lionel Gissot Jessica Marion Frédérique Tellier Patrick Moreau Béatrice Satiat-Jeunemaître Jean-Christophe Palauqui Johnathan A Napier Jean-Denis Faure

Acyl chain length is thought to be crucial for biophysical properties of the membrane, in particular during cell division, when active vesicular fusion is necessary. In higher plants, the process of cytokinesis is unique, because the separation of the two daughter cells is carried out by de novo vesicular fusion to generate a laterally expanding cell plate. In Arabidopsis thaliana, very-long-ch...

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