نتایج جستجو برای: endocrine related cancer
تعداد نتایج: 2032507 فیلتر نتایج به سال:
Endocrine disruptors (EDs) are a class of chemicals with the ability to interfere with the endocrine (hormonal) processes in mammals. Any hormonal process in the body can potentially be impacted by endocrine disruptors. As a result, EDs have been linked to many health related issues, such as learning disabilities, brain and cognitive development problems, breast cancer, deformations of limbs, f...
The prevalence of obesity is increasing which becomes worrisome due to its association with several diseases and certain types of cancers. While weight control through dietary caloric restriction and/or physical activity protects against cancer in animal models, the underlying mechanisms are not fully defined. Weight loss due to negative energy balance is associated with alterations of multiple...
BACKGROUND Endocrine therapy removes the influence of oestrogen on breast cancer cells and so hormonal treatments such as tamoxifen, megestrol acetate and medroxyprogesterone acetate have been in use for many years for advanced breast cancer. Aromatase inhibitors (AIs) inhibit oestrogen synthesis in the peripheral tissues and have a similar tumour-regressing effect to other endocrine treatments...
Purpose Cholesterol-lowering medication (CLM) has been reported to have a role in preventing breast cancer recurrence. CLM may attenuate signaling through the estrogen receptor by reducing levels of the estrogenic cholesterol metabolite 27-hydroxycholesterol. The impact of endocrine treatment on cholesterol levels and hypercholesterolemia per se may counteract the intended effect of aromatase i...
The choice of endocrine agent for breast cancer depends on the menopausal status of the patient, the stage of disease, prognostic factors, and the toxicity profile of the agent. Endocrine therapies are typically given sequentially, with the least toxic therapy given first. Tamoxifen is considered first-line endocrine therapy for all stages of breast cancer. New antiestrogens in development incl...
Long-term adverse health conditions, including secondary malignant neoplasms, are common in childhood cancer survivors. Although mortality attributable to secondary malignancies declined over the past decades, the risk for developing a solid secondary malignant neoplasm did not. Endocrine-related malignancies are among the most common secondary malignant neoplasms observed in childhood cancer s...
Background/Aim: Limited data exist on the expression pattern of TNFAIP3/A20, as assayed by immunohistochemistry (IHC), in breast cancer tissues. This study aimed to assess A20 cancer. Materials and Methods: The was analysed using IHC 50 cases retrieved from Sharjah Breast Cancer Center at University Hospital Sharjah, United Arab Emirates. Omics survival were also used analyse its association wi...
background and aims: thyroid cancer is the most common endocrine malignant and papillary cancer and three times more prevalent in women than men. the aim of this study was to evaluate the incidence rate and trend of thyroid cancer in iranian population. methods: national incidence was rated by iran national cancer registry data derived from iran’s annual national cancer registration reported fr...
Thyroid cancer is one of the most common malignancies of endocrine glands, causing carcinomas, such as papillary, follicular, medullary, and anaplastic thyroid carcinomas. Due to the significance of thyroid carcinomas, identification of the main signaling pathways and the affecting mutations has been considered by researchers. Further studies on the dysregulation of oncogenes in signaling path...
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