Valvular heart disease is the common cardiac manifestation of systemic lupus erythematosus (SLE) with a tendency for mitral valve regurgitation. In this study we report a case of mitral valve replacement for mitral stenosis caused by Libman-Sacks endocarditis in the setting of SLE. In addition, we provide a systematic review of the literature on mitral valve surgery in the presence of Libman-Sa...

O sler’s portentous words are as relevant now as when originally published. Despite improved preventive strategies, rational antibiotic prescribing, advances in imaging, and increasing use of early life saving cardiac surgery, the incidence of infective endocarditis remains high at 1.7–6.2 per 100 000 person years in the USA and Europe, with a one year mortality approaching 40%. The classical p...

Infective endocarditis triggers the development of multiple immunological reactions, including the formation of autoantibodies. Certain categories of autoantibodies triggered by endocarditis, for example, antineutrophil cytoplamic antibodies (ANCA), may cause secondary diseases that require special diagnostic approaches and at times special interventions. Formation of ANCA secondary to endocard...

Survival rates of premature infants have increased with developing technology and evolving knowledge but late-onset sepsis is more frequent due to prolonged hospitalization periods of these infants. We report the case of an extremely low birth weight premature infant who was admitted with respiratory distress syndrome, developed necrotizing enterocolitis and fungal sepsis with endocarditis by C...

A 61 years-old woman treated with methylprednisolone due to arthritis mutilans was admitted to our hospital after being found to have complete atrioventricular block and vegetation on the mitral and aortic valves. Infective endocarditis was suspected, but offending bacteria was not detected by repetitive blood cultures. Despite intensive care, we could not control the infection and she died of ...

In antiphospholipid syndrome (APS), there is a high prevalence of valvular heart disease which leads to increased risk of thrombo-embolic events, in particular, cerebrovascular events. We present a patient with cerebral infarction, previous deep-vein thrombosis, and miscarriages with positive lupus anticoagulant and anticardiolipin antibodies. Echocardiographic examination revealed mitral valve...

Background: Infective endocarditis occurs due to the presence of microorganisms in the endocardium or the heart valves. Nowadays, infective endocarditis is still a major cause of death with an incidence rate of 5 to 7.9 per 100,000 populations. The aim of the study was to determine antibiotic resistance pattern of bacterial agents isolated from blood culture of patients with infective endocardi...

Background: Group B Streptococcus (GBS) is a significant cause of invasive disease among adult non-pregnant patients with increasing incidence and mortality rates. Although non-alcoholic fatty liver (NAFLD) associated components metabolic syndrome previously recognized as risk factors for GBS, the impact NAFLD on GBS course outcomes unknown. Methods: We conducted retrospective cohort study all ...

Endocarditis is one of the most prevalent forms of cardiac involvement in patients with lupus, as it considered as a life-threatening complication. The aim of this study is to determine particularities of endocarditis in patients with lupus and to look for distinguishing features between infectious or immunological origin. A retrospective study was conducted on patients with lupus presenting en...

Ventricular tachycardia (VT) has been described as one of the possible complication of acute coronary syndrome. Although the majority of acute coronary syndrome (ACS) cases are caused by plaque rupture, coronary embolism from infective vegetation has been reported as a rare etiology of acute myocardial infarction. Identifying of this rare complication is crucial in management of the patient. We...