Dopaminergic drugs affect a variety of cognitive processes, but the direction and extent of effects vary across individuals and tasks. Paradoxical effects are observed, by which the same drug causes cognitive enhancing as well as adverse effects. Here, we demonstrate that individual differences in impulsive personality account for the contrasting effects of dopaminergic drugs on working memory ...

Studies of human subjects performing cognitive tasks on and off dopaminergic drugs have suggested a specific role of dopamine in cognitive processes, particularly in working memory and prefrontal "executive" functions. However, the cortical effects of these drugs have been poorly understood. We used functional magnetic resonance imaging (fMRI) to examine both task-specific and general changes i...

epilepsy is accompanied with a strong change in neuronal activity not only in excitatory (glutamatergic) and inhibitory (gabaergic) neurotransmission, but also in neuromodulatory agents. dopaminergic system, as an important neuromodulatory system of the brain, has significant effect on neuronal excitability. in addition, this system undergoes many changes in epileptic brain. understanding the e...

Introduction: The induction of human umbilical cord-derived mesenchymal stem cells (HUC-MSCs) toward dopaminergic neurons is a major challenge in tissue engineering and experimental and clinical treatments of various neurodegenerative diseases, including Parkinson disease. This study aims to differentiate HUC-MSCs into dopaminergic neuron-like cells. Methods: Following the isolation and charac...

319 From 1987 to the present our Cuban Centre has performed more than 30 foetal nigral transplants to the striatum in patients with Parkinson's disease. To study the improvement reported in dopaminergic drug response and the decrease L-Dopa daily dose together with better motor performance /1/, the present pharmacological trial was applied to four Parkinsonian patients, who underwent stereotact...

Parkinson's disease (PD) is associated with emotional abnormalities. Dopaminergic medications ameliorate Parkinsonian motor symptoms, but less is known regarding the impact of dopaminergic agents on affective processing, particularly in depressed PD (dPD) patients. The aim of this study was to examine the effects of dopaminergic pharmacotherapy on brain activation to emotional stimuli in depres...

The immobilization of brain dopamine receptors (primary targets in the treatment of schizophrenia, Parkinson’s disease, and Huntington’s chorea) on a solid support can represent an appealing strategy for the realization of biosensors for dopamine and dopaminergic drugs. Our final goal is the realization of an optical biosensor that allows parallel quantitative analysis, with different receptors...

Chronic administration of selective serotonin reuptake inhibitors (SSRI) enhances dopaminergic activity. However, the role of enhanced dopaminergic transmission in the therapeutic effects of this kind of antidepressants is still unclear. Drugs producing dopaminergic activation lead to an increment in general activity. Thus, it is reasonable to assume that some of the therapeutic effects of SSRI...

Antipsychotic drugs with greater efficacy and tolerance have been sought and studied in recent years. Some of them could be used in new treatment strategies to replace the D(2) receptor antagonism induced by classic neuroleptics such as haloperidol. The development strategies in this field are not only focused on discovering specific antagonists of one subtype of dopaminergic receptor, but on t...

Abstract Parkinson’s Disease (PD) is one of the most frequent disorders central nervous system (CNS). PD an age-related disease in that morbidity increases with age. The main symptoms it are motor like bradykinesia, rigidity and resting tremor. These diminish comfort patient’s life may lead to immobility. Hence, rapid diagnosis start treatment very important. pharmacotherapy difficult. involves...