The present work deals with the comparison of in vitro dissolution profiles of fenofibrate liquisolid tablet formulations with those of marketed fenofibrate tablets, and the application of statistical methods to evaluate each method for its usefulness. The methods used to study dissolution profile comparison include Model independent method (Similarity factor, f2); Model dependent methods (Zero...

We demonstrate the use of modeling and simulation to investigate bioequivalence (BE) concerns raised about generic warfarin products. To test the hypothesis that the loss of isopropyl alcohol and slow dissolution in acidic pH has significant impact on the pharmacokinetics of warfarin sodium tablets, we conducted physiologically based pharmacokinetic absorption modeling and simulation using form...

[1] We argue that diagnostics of excess dissolved calcium carbonate (TA*) above the saturation horizon cannot be unambiguously interpreted in terms of local in situ dissolution. We examine a three-dimensional numerical model of global ocean circulation and biogeochemistry with explicit representation of the formation and dissolution of calcium carbonate. In particular, dissolution is only allow...

The potential of liquisolid systems to improve the dissolution properties of a water-insoluble agent (indomethacin) was investigated. In this study, different formulations of liquisolid tablets using different co-solvents (non-volatile solvents) were prepared and the effect of aging on the dissolution behaviour of indomethacin liquisolid compacts was investigated. To evaluate any interaction be...

This paper presents results of a pharmacokinetics study concerning pentoxifylline and its main metabolites after administration of extended release formulation of Trental 400 mg and correlation of this pharmacokinetics with in vitro dissolution test results of parent drug. In order to establish most relevant in vitro test, dissolution was performed in different experimental conditions (stirring...

A good correlation should be obtained between data derived from in vitro dissolution and bioavailability studies on drug delivery systems if bioavailability parameters are to be reliably predicted from the in vitro dissolution variables. This study compares the in vivo absorption with the in vitro dissolution profiles into various dissolution media of a novel controlled release theophylline cap...

Surface carbonate sediments from sites on the Bahamas Bank with different seagrass densities were incubated across a range of O2 delivery rates, to study the controls on metabolic carbonate dissolution in these sediments. The results confirmed the 1:1 ratio between the rates of O2 consumption and carbonate dissolution, demonstrating that microbial respiration was the ratelimiting step in metabo...

The dissolution of powder drugs, besides being a topic of utmost importance, especially for the sparingly soluble ones, is far from being well-explained. The purpose of the present study is, on the one hand, to obtain experimental dissolution profiles and, on the other hand, to analyze and process the data for dissolution modeling. Three different size fractions of a widely used sparingly solub...

PURPOSE Unlike orthodox medicines, specific guidelines for dissolution testing of complementary/alternate (CAMs) and traditional medicines (TMs) have not been developed nor is dissolution testing a requirement for the quality control of such products. In this report, the dissolution of African Potato (AP) products, an African traditional medicine (ATM) which has been ingested by man for a diver...

the potential of liquisolid systems to improve the dissolution properties of a water-insoluble agent (indomethacin) was the purpose of this survey. in this study, different formulations of liquisolid tablets using different co-solvents (non-volatile solvents) were prepared and the effect of several amounts of them on the dissolution behaviour of indomethacin was investigated. it is worth mentio...