We previously reported that a liposome-mannan vaccine (L-mann) of Candida albicans induces production of mouse antibodies that protect against disseminated candidiasis and vaginal infection. Immunoglobulin M (IgM) monoclonal antibody (MAb) B6.1, specific for a C. albicans cell surface beta-1,2-mannotriose, protects mice against both infections. Another IgM MAb, termed B6, which is specific for ...

EditoriaL 240 Virulence Volume 5 issue 2 In vitro models, in which Candida albicans is incubated with one or more type of host cell, are a powerful tool for dissecting the pathogenesis of infection. Using these models, investigators have elucidated important responses of both the host and the fungus that influence the outcome of infection. In addition, tissue culture models have been invaluable...

Junvenile diabetes mellitus may present acutely as diabetic ketoacidosis or with a chronic history of polyuria, polydipsia and polyphagia. Uncommon presentations include unexplained fever and weight loss, abdominal pain and secondary enuresis. Pyogenic skin infections and monilial vaginitis in teenage girls and adults may be present at the time of diagnosis but are rarely the sole presenting fe...

Two commercially available Bifidobacterium spp. (Bifidobacterium infantis and Bifidobacterium lactis) were compared for their capacities to protect immunodeficient bg/bg-nu/nuand bg/bg-nu/+mice from orogastric and lethal candidiasis. Both Bifidobacterium spp. prolonged the survival of Candida albicans-colonized adult and neonatal bg/bg-nu/numice. The bifidobacteria affected the production of an...

Candida albicans is the most common cause of hematogenously disseminated candidiasis, and this disease is particularly prevalent in immunocompromised patients. The mortality of invasive candidiasis remains 40% to 50% even with the proper treatment with current antifungal drugs. Recently, with the better understanding of host-fungus interactions, notable progress has been made in antifungal vacc...